Evaluate the Safety and Pharmacokinetics/Pharmacodynamics of HS-20118 (NCT06846710)
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of HS-20118 in Adult Participants
🩺 Plain-English Summary (8th-Grade Level)
The study will be conducted in 2 parts (SAD for Part 1 and MAD for Part2). Part 1 is a single-center, randomized, double-blind, placebo-controlled, SAD study to evaluate the safety, tolerability, immunogenicity, and PK of HS-20118 after a single oral dose in healthy participants. Part 2 is a multi-center, randomized, double-blind, placebo-controlled, MAD study to evaluate the safety, tolerability, immunogenicity, PK, and PD of HS-20118 after multiple oral doses in patients with moderate to severe plaque psoriasis .
Who can join: Review the eligibility criteria below.
Location: Kinetic Clinical Research — Anaheim, California
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- Kinetic Clinical Research — Anaheim, California
- Clinitiative - Floridian Clinical Research, LLC — Miami Lakes, Florida
- NuLine Clinical Trial Center (Network) — Pompano Beach, Florida
- Pacific Clinical Research Network (PCRN), Auckland — Takapuna, Auckland
- Pacific Clinical Research Network (PCRN), Christchurch — Christchurch, Christchurch
- Momentum Clinical Research, Dunedin — Dunedin, Dunedin
- Momentum Clinical Research, Pukekohe — Pukekohe, Pukekohe
- Pacific Clinical Research Network (PCRN), Wellington — Upper Hutt, Upper Hutt
- Momentum Clinical Research, Wellington — Mount Cook, Wellington Region
📞 Contact the Study Coordinator
Phone: (714) 441-9178
Email: marguerite.critelli@kineticclinical.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Psoriasis
- Deucravacitinib Adherence Study — Winston-Salem, North Carolina
- An Open-label, Single-dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Brodalumab in Pediatric Subjects — San Diego, California
- Psoriasis Longitudinal Assessment and Registry — Birmingham, Alabama
- Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977 — Birmingham, Alabama
- Long-Term Study That Measures the Safety and Efficacy of Deucravacitinib (BMS-986165) in Participants With Psoriasis — Birmingham, Alabama
- Prevention of Cardiovascular Disease and Mortality in Patients With Psoriasis or Psoriatic Arthritis — Scottsdale, Arizona
Explore by condition: All Psoriasis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.