๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-02

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO) (NCT06857942)

A Phase 4, Prospective, Open-Label, Single Arm Study to Assess the Effectiveness of Tirzepatide After Initiation of Ixekizumab in Adult Participants With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight in Clinical Practice

๐ŸŸข Recruiting Phase4 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Eli Lilly and Company

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

Who can join: Review the eligibility criteria below.

Location: Medical Dermatology Specialists โ€” Phoenix, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (40 Sites)

Showing the first 25 of 40 sites.

  • Medical Dermatology Specialists โ€” Phoenix, Arizona
  • First OC Dermatology Research Inc โ€” Fountain Valley, California
  • Center For Dermatology Clinical Research, Inc. โ€” Fremont, California
  • Metropolis Dermatology โ€” Los Angeles, California
  • Northridge Clinical Trials โ€” Northridge, California
  • NeoClinical Research โ€” Hialeah, Florida
  • Skin Care Research โ€” Hollywood, Florida
  • Encore Medical Research โ€” Hollywood, Florida
  • MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research โ€” Tampa, Florida
  • TruDerm & TruSpa โ€” Wellington, Florida
  • Southeast Research Specialists โ€” Douglasville, Georgia
  • Dawes Fretzin Clinical Research Group, LLC โ€” Indianapolis, Indiana
  • The Indiana Clinical Trials Center, PC โ€” Plainfield, Indiana
  • Equity Medical - Bowling Green โ€” Bowling Green, Kentucky
  • Dermatology and Skin Cancer Specialists, LLC โ€” Rockville, Maryland
  • Metro Boston Clinical Partners โ€” Brighton, Massachusetts
  • David Fivenson, MD, PLC โ€” Ann Arbor, Michigan
  • Great Lakes Research Group, Inc. โ€” Bay City, Michigan
  • The Derm Institute of West Michigan โ€” Caledonia, Michigan
  • Skin Cancer and Dermatology Institute - Reno โ€” Reno, Nevada
  • Stracskin โ€” Portsmouth, New Hampshire
  • Psoriasis Treatment Center of Central New Jersey โ€” East Windsor, New Jersey
  • Care Access - Hoboken โ€” Hoboken, New Jersey
  • Equity Medical โ€” New York, New York
  • Revival Research Institute, LLC โ€” Cary, North Carolina

๐Ÿ“ž Contact the Study Coordinator

Phone: (317) 615-4559

Email: LillyTrials@Lilly.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Psoriasis clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—