Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines (NCT06929455)
Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines: Trained Human Sensory Panels
🩺 Plain-English Summary (8th-Grade Level)
Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingredients (substances in medications that produce desired health effects). After tasting each sample participants will spit out the sample and rinse with water (no samples will be swallowed). Active pharmaceutical ingredients of current interest are: 1) tenofovir alafenamide, used to treat HIV infection and hepatitis B, 2) rifampicin, used to treat tuberculosis, 3) rifapentine, used to treat tuberculosis, and 4) levofloxacin, used to treat various bacterial infections). Other active pharmaceutical ingredients may be added as the study goes forward. Participants will be instructed to taste samples both with and without experimental flavor ingredients added and judge how the samples taste. People who volunteer for the study will be instructed to complete many repeated visits to the Monell Center (University City area of Philadelphia) for tasting sessions. Tasting visits will last between 1 and 2 hours.
Who can join: Review the eligibility criteria below.
Location: Monell Chemical Senses Center — Philadelphia, Pennsylvania
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
- Flavor additives (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Monell Chemical Senses Center — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (267) 519-4799
Email: TasteOfMedicinesStudy@monell.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Healthy Adults
- Transcutaneous Spinal Cord Stimulation in Healthy Adults — Chicago, Illinois
- The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood, — Columbus, Ohio
- The Healthy Cookie Energy Study: Understanding How Healthy Cookies Affect Mitochondrial Biology — Columbus, Ohio
- Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans — Austin, Texas
- Validation of NAD+ Measurements for Human Clinical Studies — Philadelphia, Pennsylvania
- A Study to Learn About How Food Affects the Uptake of Study Medicine Prifetrastat Into the Blood in Healthy Adults — New Haven, Connecticut
Explore by condition: All Healthy Adults clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.