A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer (NCT06948448)

🧪 Interventions in This Study

• ONO-4578 (DRUG)
• Opdivo® (DRUG)
• Oxaliplatin (DRUG)
• 5-Fluorouracil (DRUG)
• Bevacizumab (DRUG)
• Leucovorin (DRUG)

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (39 Sites)

Showing the first 25 of 39 sites.

• Mayo Clinic Arizona — Phoenix, Arizona
• USC Norris Comprehensive Cancer Center — Los Angeles, California
• Rocky Mountain Cancer Centers, LLP — Lone Tree, Colorado
• Mayo Clinic Florida — Jacksonville, Florida
• Advent Health — Orlando, Florida
• May Clinic Rochester — Rochester, Minnesota
• The Ohio State University Comprehensive Cancer Center — Columbus, Ohio
• Thomas Jefferson University, Sidney Kimmel Cancer Center — Philadelphia, Pennsylvania
• Baylor Scott & White Medical Center — Temple, Texas
• Virginia Oncology Associates — Norfolk, Virginia
• Blue Ridge Cancer Care — Salem, Virginia
• The Ottawa Hospital Cancer Centre — Ottawa, Ontario
• Princess Margaret Cancer Centre- University Health Network — Toronto, Ontario
• Jewish General Hospital — Montreal, Quebec
• CHU Besançon - Hôpital Jean Minjoz — Besançon, Doubs
• CHU Bordeaux - Hôpital Haut-Lévêque — Pessac, Gironde
• Chru De Nantes Hotel-Dieu — Nantes, Loire Atlantique
• Hôpital de la Timone — Marseille, Marseille
• Hôpital Européen Georges Pompidou — Paris, Paris
• Hôpital Saint-Antoine — Paris, Paris
• Centre Leon Berard — Lyon, Rhone
• CHU Poitiers - Hôpital la Milétrie — Poitiers, Vienne
• Azienda Socio Sanitaria Territoriale Niguarda — Milan, Italy
• Istituto Clinico Humanitas — Milan, Italy
• Istituto Europeo di Oncologia — Milan, Italy

📞 Contact the Study Coordinator

Phone: (866) 587-7745

Email: clinical_trial@ono-pharma.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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• Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD) — Houston, Texas
• Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver — Basking Ridge, New Jersey
• The PRIME-CRC Trial to Promote CRC Screening in Rural Communities — Bastrop, Louisiana
• Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer — Concord, California

Explore by condition: All Colorectal Cancer clinical trials

💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Contact the study coordinator using the phone/email above.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.