🏛️ Verified NIH Record • Updated 2026-08-26

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC) (NCT06979336)

A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Genentech, Inc.

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.

Who can join: Review the eligibility criteria below.

Location: Gastro Care Institute — Lancaster, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (106 Sites)

Showing the first 25 of 106 sites.

  • Gastro Care Institute — Lancaster, California
  • Medical Associates Research Group, Inc. — San Diego, California
  • Peak Gastroenterology Associates — Colorado Springs, Colorado
  • Clinical Research of Osceola, LLC — Kissimmee, Florida
  • University of Chicago Medical Center — Chicago, Illinois
  • Intercity Gastroenterology — Fresh Meadows, New York
  • Monroe Biomedical Research — Monroe, North Carolina
  • University of Utah Hospitals & Clinics — Salt Lake City, Utah
  • Mater Misericordiae Limited — South Brisbane, Queensland
  • Royal Melbourne Hospital — Parkville VIC, Victoria
  • Fiona Stanley Hospital — Murdoch, Western Australia
  • HUWC - UFC - Hospital Universitrio Walter Cantdio - Universidade Federal do Cear — Fortaleza, Ceará
  • L2IP ?Instituto de Pesquisas Clínicas Ltda. — Brasília, Federal District
  • Chronos Pesquisa Clinica — Brasília, Federal District
  • Hospital Felicio Rocho — Belo Horizonte, Minas Gerais
  • Associao Paranaense de Cultura APC — Curitiba, Paraná
  • Centro Digestivo de Curitiba — Curitiba, Paraná
  • Hospital de Clnicas de Porto Alegre — Porto Alegre, Rio Grande do Sul
  • Hospital Ernesto Dornelles — Porto Alegre, Rio Grande do Sul
  • Newdata Clinical Trials — Aracaju, Sergipe
  • CECIP - Centro de Estudos Clínicos do Interior Paulista — Ja, São Paulo
  • Pesquisare Saude — Santo André, São Paulo
  • Kaiser Clinica — São José do Rio Preto, São Paulo
  • Instituto de Assistencia Medica ao Servidor Publico Estudo Estadual — São Paulo, São Paulo
  • BR Trials - Ensaios Clnicos e Consultoria — São Paulo, São Paulo

📞 Contact the Study Coordinator

Phone: (888) 662-6728

Email: global-roche-genentech-trials@gene.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗