Optimizing Reperfusion to Improve Outcomes and Neurologic Function (NCT06990867)
Optimizing Reperfusion to Improve Outcomes and Neurologic Function (ORION): A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group, Phase 2/3 Study to Evaluate the Efficacy and Safety of JX10 in Acute Ischemic Stroke With Late Presentations
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin Scale score when compared with placebo following AIS. 2. Risk of symptomatic intracranial hemorrhage of JX10 in participants with AIS. During Part 1, participants will be randomized to JX 10 (1mg/kg, 3 mg/kg) or placebo. During Part 2, participants will receive JX10 (optimal dose chosen from Part 1) or placebo.
Who can join: Review the eligibility criteria below.
Location: Corxel Investigational Site — Long Beach, California
Age range: 18 Years to 90 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (83 Sites)
Showing the first 25 of 83 sites.
- Corxel Investigational Site — Long Beach, California
- Corxel Investigational Site — Sacramento, California
- Corxel Investigational Site — Colorado Springs, Colorado
- Corxel Investigational Site — Washington D.C., District of Columbia
- Corxel Investigational Site — Delray Beach, Florida
- Corxel Investigational Site — Chicago, Illinois
- Corxel Investigational Site — Wichita, Kansas
- Corxel Investigational Site — Baltimore, Maryland
- Corxel Investigational Site — Kalamazoo, Michigan
- Corxel Investigational Site — Traverse City, Michigan
- Corxel Investigational Site — St Louis, Missouri
- Corxel Investigational Site — Great Neck, New York
- Corxel Investigational Site — New York, New York
- Corxel Investigational Site — Toledo, Ohio
- Corxel Investigational Site — Tulsa, Oklahoma
- Corxel Investigational Site — Dallas, Texas
- Corxel Investigational Site — Houston, Texas
- Corxel Investigational Site — Ghent,
- Corxel Investigational Site — Blagoevgrad,
- Corxel Investigational Site — Burgas,
- Corxel Investigational Site — Pleven,
- Corxel Investigational Site — Plovdiv,
- Corxel Investigational Site — Sofia,
- Corxel Investigational Site — Edmonton,
- Corxel Investigational Site — Kingston,
📞 Contact the Study Coordinator
Phone: (201) 268-3723
Email: Information.center@corxelbio.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke — Buffalo, New York
- Safety Of A Second Dose Of Tenecteplase In Selected Acute Ischemic Stroke Patients Not Responding To The First Dose — Houston, Texas
- Efficacy and Safety of Xinglou Chengqi Granule for Acute Ischemic Stroke — Richmond, British Columbia
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Explore by condition: All Acute Ischemic Stroke clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.