A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event (NCT07000123)
A Phase III, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Effect of AZD0780 on Low-Density Lipoprotein Cholesterol in Patients With Elevated Low Density Lipoprotein Cholesterol and Clinical Atherosclerotic Cardiovascular Disease or at Risk for a First Atherosclerotic Cardiovascular Disease Event
🩺 Plain-English Summary (8th-Grade Level)
This is a study to evaluate the efficacy and safety of AZD0780 in adults with clinical ASCVD or who are at risk for a first ASCVD event and who have elevated LDL-C. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of study. The total length of the study for an individual participant will be up to approximately 56 weeks, including a screening period of up to 14 days, treatment with AZD0780 or placebo for 52 weeks, and a safety follow-up period of 10 days.
Who can join: Review the eligibility criteria below.
Location: Research Site — Huntsville, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (404 Sites)
Showing the first 25 of 404 sites.
- Research Site — Huntsville, Alabama
- Research Site — Irondale, Alabama
- Research Site — Mobile, Alabama
- Research Site — Gilbert, Arizona
- Research Site — Phoenix, Arizona
- Research Site — Sun City West, Arizona
- Research Site — Garden Grove, California
- Research Site — Gardena, California
- Research Site — Lancaster, California
- Research Site — Lincoln, California
- Research Site — San Diego, California
- Research Site — San Diego, California
- Research Site — Torrance, California
- Research Site — West Hills, California
- Research Site — Hamden, Connecticut
- Research Site — Boca Raton, Florida
- Research Site — Hallandale, Florida
- Research Site — Hialeah, Florida
- Research Site — Inverness, Florida
- Research Site — Jacksonville, Florida
- Research Site — Miami, Florida
- Research Site — New Port Richey, Florida
- Research Site — Orlando, Florida
- Research Site — Pembroke Pines, Florida
- Research Site — Seminole, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.