🏛️ Verified NIH Record • Updated 2026-07-27

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma (NCT07015242)

The CAROLYN Trial: Lisocabtagene Maraleucel as First-Line Therapy for Primary Central Nervous System Lymphoma (PCNSL) in Transplant-Ineligible Patients

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety and efficacy of lisocabtagene maraleucel (Breyanzi/liso-cel/BMS-986387) in adults as first-line treatment in transplant-ineligible Primary Central Nervous System Lymphoma (PCNSL).

Who can join: Review the eligibility criteria below.

Location: University Of Colorado — Aurora, Colorado

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (40 Sites)

Showing the first 25 of 40 sites.

  • University Of Colorado — Aurora, Colorado
  • Moffitt Cancer Center — Tampa, Florida
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago, Illinois
  • Dana-Farber Cancer Institute — Boston, Massachusetts
  • Washington University School of Medicine in St. Louis — St Louis, Missouri
  • Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey
  • Roswell Park Comprehensive Cancer Center — Buffalo, New York
  • Memorial Sloan Kettering Cancer Center — New York, New York
  • Cleveland Clinic — Cleveland, Ohio
  • The Ohio State University Comprehensive Cancer Center — Columbus, Ohio
  • University of Pennsylvania — Philadelphia, Pennsylvania
  • Sarah Cannon Research Institute Oncology Partners — Nashville, Tennessee
  • MD Anderson Cancer Center — Houston, Texas
  • Fred Hutchinson Cancer Center — Seattle, Washington
  • Local Institution - 0111 — Nice, Alpes-Maritimes
  • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu — Nantes, Loire-Atlantique
  • Local Institution - 0103 — Pierre-Bénite, Rhône
  • CHU de Dijon Bourgogne - Hopital Francois Mitterand — Dijon,
  • Chru De Lille - Hopital Claude Huriez — Lille,
  • Local Institution - 0112 — Marseille,
  • CHU Montpellier — Montpellier,
  • Local Institution - 0114 — Paris,
  • Local Institution - 0102 — Paris,
  • Local Institution - 0108 — Pessac,
  • CHU de Rennes - Hopital de Pontchaillou — Rennes,

📞 Contact the Study Coordinator

Phone: (855) 907-3286

Email: Clinical.Trials@bms.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Lymphoma clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗