Who is eligible for clinical trial NCT07148414?

Participants must meet protocol criteria for Rheumatoid Arthritis. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07148414 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-06-03

A Study of SPY072 in Rheumatic Disease (NCT07148414)

Phase 2 Study to Assess the Efficacy and Safety of SPY002-072 in Adults With Moderately to Severely Active Rheumatologic Disease

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Spyre Therapeutics, Inc.

🩺 Plain-English Summary (8th-Grade Level)

This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease (RD).

Who can join: Review the eligibility criteria below.

Location: Site 113 — Avondale, Arizona

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (64 Sites)

Showing the first 25 of 64 sites.

Site 113 — Avondale, Arizona
Site 118 — Tucson, Arizona
Site 114 — Chula Vista, California
Site 111 — Covina, California
Site 108 — Tujunga, California
Site 112 — Upland, California
Site 107 — Whittier, California
Site 115 — Aventura, Florida
Site 109 — Hialeah, Florida
Site 106 — Ormond Beach, Florida
Site 110 — Tampa, Florida
Site 116 — Willowbrook, Illinois
Site 119 — Rockville, Maryland
Site 104 — Duncansville, Pennsylvania
Site 105 — Corpus Christi, Texas
Site 120 — Irving, Texas
Site 103 — Tomball, Texas
Site 102 — Tomball, Texas
Site 503 — Lovech, Lovech
Site 502 — Pleven, Pleven
Site 506 — Plovdiv, Plovdiv
Site 505 — Plovdiv, Plovdiv
Site 504 — Varna, Varna
Site 706 — Hlučín, Hlučín
Site 702 — Moravská Ostrava, Ostrava-město

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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Explore by condition: All Rheumatoid Arthritis clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗