A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee (NCT07153471)
A Phase 3 Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee: A Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Who can join: Review the eligibility criteria below.
Location: Arizona Research Center — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (96 Sites)
Showing the first 25 of 96 sites.
- Arizona Research Center — Phoenix, Arizona
- AMR Clinical — Tempe, Arizona
- Care Access - Huntington Beach — Huntington Beach, California
- Care Access - Thousand Oaks — Thousand Oaks, California
- Legacy Clinical Trials — Colorado Springs, Colorado
- Chase Medical Research, LLC — Waterbury, Connecticut
- Care Access - Decatur — Decatur, Georgia
- North Georgia Clinical Research — Woodstock, Georgia
- Northwestern University — Chicago, Illinois
- AMR Clinical — Newton, Kansas
- MedVadis Research Corporation — Waltham, Massachusetts
- StudyMetrix Research — City of Saint Peters, Missouri
- AMR Clinical — Kansas City, Missouri
- Cardio Metabolic Institute — Somerset, New Jersey
- Carolina Research Center — Shelby, North Carolina
- University Orthopedics Center — Altoona, Pennsylvania
- Care Access - Rapid City — Rapid City, South Dakota
- AMR Clinical — Knoxville, Tennessee
- Mercy Family Clinic — Dallas, Texas
- Juno Research — Houston, Texas
- Biopharma Informatic, LLC — Houston, Texas
- Activian Clinical Research — Kingwood, Texas
- Advanced Rheumatology of Houston - Woodlands — The Woodlands, Texas
- Charlottesville Medical Research — Charlottesville, Virginia
- Gershon Pain Specialists — Virginia Beach, Virginia
📞 Contact the Study Coordinator
Phone: (317) 615-4559
Email: LillyTrials@Lilly.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Osteoarthritis
- FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry — Worcester, Massachusetts
- Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System — San Francisco, California
- Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) — Miami, Florida
- Persona Partial Knee Clinical Outcomes Study — Fremont, California
- Evaluation of Biomarkers in Human Synovial Fluid — Durham, North Carolina
- Comprehensive Nano - Post Market Clinical Follow-Up Study — Graz, Styria
Explore by condition: All Osteoarthritis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.