A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation (NCT07187115)
A Global Randomized Trial Comparing Pulsed Field Ablation of Pulmonary Veins Plus Extra-PV Sources Utilizing Electrographic Flow Mapping Versus Pulmonary Veins Plus Posterior Wall in Persistent Atrial Fibrillation Patients.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to establish the safety of the pulsed field ablation (PFA) therapy of Pulmonary Veins and Electrographic Flow (EGF) identified extra-PV sources of atrial fibrillation (PVI + EGF ablation of sources) and to demonstrate its non-inferiority in effectiveness compared to PFA of Pulmonary Veins and LA Posterior Wall (PVI+ PWA) in the treatment of de novo symptomatic drug-refractory persistent atrial fibrillation (PersAF).
Who can join: Review the eligibility criteria below.
Location: Arrhythmia Research Group — Jonesboro, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (15 Sites)
- Arrhythmia Research Group — Jonesboro, Arkansas
- Pacific Heart Institute — Santa Monica, California
- Piedmont Athens Regional — Athens, Georgia
- Emory University Hospital — Atlanta, Georgia
- St. Luke's Boise Medical Center — Boise, Idaho
- Mount Sinai Medical Center — New York, New York
- Cleveland Clinic Foundation — Cleveland, Ohio
- Ohio State University Medical Center — Columbus, Ohio
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
- Texas Cardiac Arrhythmia Research Foundation — Austin, Texas
- Christus Trinity Mother Frances Health System — Tyler, Texas
- AZORG — Aalst,
- Hartcentrum Hasselt Jessa Ziekenhuis Campus Virga Jesse — Hasselt,
- Prince of Wales Hosptial — Shatin, Hong Kong
- Clinica Universidad de Navarra — Pamplona, Navarre
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation (AF)
- Detection and Classification of Cardiac Rhythm and Atrial Fibrillation Using a Finger-worn Ring — La Jolla, California
- Phase-Aligned Atrial Fibrillation Mapping — Cleveland, Ohio
- Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF) — Milwaukee, Wisconsin
- AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment — Los Angeles, California
- P-wave Duration and Local Potential as Predictors of AF Recurrence Following Pulmonary Vein Isolation — Paramus, New Jersey
- Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation — Huntsville, Alabama
Explore by condition: All Atrial Fibrillation (AF) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.