A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease (NCT07214727)
A Phase 1, Randomized, Placebo-controlled Study With a Double Blind Period With Open-label Extension Period to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-5288 in Adult Patients With Alzheimer's Disease
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to: * Evaluate the safety and tolerability of intrathecal (IT) ALN-5288 in patients with Alzheimer's Disease (AD) * Evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ALN-5288 after dose administration
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — Montreal
Age range: 40 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- Clinical Trial Site — Montreal,
- Clinical Trial Site — Ottawa,
- Clinical Trial Site — Toronto,
- Clinical Trial Site — Toronto,
- Clinical Trial Site — 's-Hertogenbosch,
- Clinical Trial Site — Amsterdam,
- Clinical Trial Site — Barcelona,
- Clinical Trial Site — Madrid,
- Clinical Trial Site — Sant Cugat del Vallès,
- Clinical Trial Site — Glasgow,
- Clinical Trial Site — London,
- Clinical Trial Site — Sheffield,
- Clinical Trial Site — Southampton,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.