A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201) (NCT07221500)
A Single-arm, Phase 2, Open-label, Multicenter Study to Evaluate NX-5948 in Adults With Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Previously Exposed to a Bruton's Tyrosine Kinase Inhibitor (BTKi) and a B-cell Lymphoma-2 Inhibitor (BCL-2i)
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a study for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have previously received treatment with a BTK inhibitor (covalent and non-covalent) and a BCL-2 inhibitor. The main purpose of this study is to test if NX-5948 (bexobrutideg) works to treat patients with CLL/SLL. Participation could last up to 5 years, and possibly longer, if the disease does not progress.
Who can join: Review the eligibility criteria below.
Location: City of Hope โ Duarte, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (37 Sites)
Showing the first 25 of 37 sites.
- City of Hope โ Duarte, California
- Cedars-Sinai Medical Center โ Los Angeles, California
- Scripps Health โ San Diego, California
- Colorado Blood Institute โ Denver, Colorado
- University of Miami โ Coral Gables, Florida
- Florida Cancer Specialists โ Sarasota, Florida
- Fort Wayne Oncology and Hematology โ Fort Wayne, Indiana
- Hematology Oncology of Indiana โ Indianapolis, Indiana
- University of Iowa โ Iowa City, Iowa
- Maryland Oncology Hematology โ Silver Spring, Maryland
- Karmanos Cancer Center โ Detroit, Michigan
- Duke University โ Durham, North Carolina
- Novant Health Cancer Institute โ Winston-Salem, North Carolina
- University of Cincinnati โ Cincinnati, Ohio
- The Cleveland Clinic Foundation โ Cleveland, Ohio
- The Ohio State University โ Columbus, Ohio
- Oncology Hematology Care โ Fairfield, Ohio
- UPMC Hillman Cancer Center โ Pittsburgh, Pennsylvania
- SCRI Oncology Partners โ Nashville, Tennessee
- Texas Oncology - Center South โ Austin, Texas
- University of Utah โ Salt Lake City, Utah
- Virginia Cancer Specialists, PC โ Fairfax, Virginia
- Oncology & Hematology Associates of Southwest VA โ Norfolk, Virginia
- Virginia Oncology Associates โ Norfolk, Virginia
- Fred Hutchinson Cancer Center โ Seattle, Washington
๐ Contact the Study Coordinator
Phone: (415) 417-3418
Email: clinicaltrials@nurixtx.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Chronic Lymphocytic Leukemia (CLL)
- The Combination of Venetoclax and Obinutuzumab in People With Chronic Lymphocytic Leukemia (CLL) โ Stanford, California
- Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax โ Basking Ridge, New Jersey
- A Trial of "Armored" CAR T Cells Targeting CD19 For Patients With Relapsed CD19+ Hematologic Malignancies โ New York, New York
- Acalabrutinib, Venetoclax, and Obinutuzumab for Initial Therapy of CLL โ Stamford, Connecticut
- A Phase 2 Trial Of The Bruton Tyrosine Kinase Degrader BGB-16673 In Combination With BCL-2 Inhibitor Sonrotoclax For Patients With Treatment-Naive Chronic Lymphocytic Leukemia (CLL) โ Houston, Texas
- Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib โ Bethesda, Maryland
Explore by condition: All Chronic Lymphocytic Leukemia (CLL) clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.