๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-17

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201) (NCT07221500)

A Single-arm, Phase 2, Open-label, Multicenter Study to Evaluate NX-5948 in Adults With Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Previously Exposed to a Bruton's Tyrosine Kinase Inhibitor (BTKi) and a B-cell Lymphoma-2 Inhibitor (BCL-2i)

๐ŸŸข Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Nurix Therapeutics, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a study for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have previously received treatment with a BTK inhibitor (covalent and non-covalent) and a BCL-2 inhibitor. The main purpose of this study is to test if NX-5948 (bexobrutideg) works to treat patients with CLL/SLL. Participation could last up to 5 years, and possibly longer, if the disease does not progress.

Who can join: Review the eligibility criteria below.

Location: City of Hope โ€” Duarte, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (37 Sites)

Showing the first 25 of 37 sites.

  • City of Hope โ€” Duarte, California
  • Cedars-Sinai Medical Center โ€” Los Angeles, California
  • Scripps Health โ€” San Diego, California
  • Colorado Blood Institute โ€” Denver, Colorado
  • University of Miami โ€” Coral Gables, Florida
  • Florida Cancer Specialists โ€” Sarasota, Florida
  • Fort Wayne Oncology and Hematology โ€” Fort Wayne, Indiana
  • Hematology Oncology of Indiana โ€” Indianapolis, Indiana
  • University of Iowa โ€” Iowa City, Iowa
  • Maryland Oncology Hematology โ€” Silver Spring, Maryland
  • Karmanos Cancer Center โ€” Detroit, Michigan
  • Duke University โ€” Durham, North Carolina
  • Novant Health Cancer Institute โ€” Winston-Salem, North Carolina
  • University of Cincinnati โ€” Cincinnati, Ohio
  • The Cleveland Clinic Foundation โ€” Cleveland, Ohio
  • The Ohio State University โ€” Columbus, Ohio
  • Oncology Hematology Care โ€” Fairfield, Ohio
  • UPMC Hillman Cancer Center โ€” Pittsburgh, Pennsylvania
  • SCRI Oncology Partners โ€” Nashville, Tennessee
  • Texas Oncology - Center South โ€” Austin, Texas
  • University of Utah โ€” Salt Lake City, Utah
  • Virginia Cancer Specialists, PC โ€” Fairfax, Virginia
  • Oncology & Hematology Associates of Southwest VA โ€” Norfolk, Virginia
  • Virginia Oncology Associates โ€” Norfolk, Virginia
  • Fred Hutchinson Cancer Center โ€” Seattle, Washington

๐Ÿ“ž Contact the Study Coordinator

Phone: (415) 417-3418

Email: clinicaltrials@nurixtx.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—