A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough (NCT07288528)
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough (FORTITUDE)
🩺 Plain-English Summary (8th-Grade Level)
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory assessment of potential synergy in combining these interventions, and the long-term outcomes of these treatments in patients with refractory or unexplained chronic cough.
Who can join: Review the eligibility criteria below.
Location: Respiratory Clinical Trials Centre, University of Calgary — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- Respiratory Clinical Trials Centre, University of Calgary — Calgary, Alberta
- Respiratory Research Lab, McMaster University — Hamilton, Ontario
- St Joseph's Health Care London — London, Ontario
- Institut universitaire de cardiologie et de pneumologie de Quebec - University Laval — Québec, Quebec
- Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke — Sherbrooke, Quebec
📞 Contact the Study Coordinator
Phone: (905) 521-2100
Email: satiai@mcmaster.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cough
- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough — Foley, Alabama
- Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures — New York, New York
- Stimulation of the Larynx to Treat Unexplained Chronic Cough — Minneapolis, Minnesota
- A Non-pharmacological Cough Control Therapy — Hamilton, Ontario
- Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough — Birmingham, Alabama
Explore by condition: All Cough clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.