Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial (NCT07293260)
A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating the Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed by Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).
Who can join: Review the eligibility criteria below.
Location: Bridgeport Hospital — Bridgeport, Connecticut
Age range: 35 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (40 Sites)
Showing the first 25 of 40 sites.
- Bridgeport Hospital — Bridgeport, Connecticut
- Jacksonville Center for Clinical Research — Jacksonville, Florida
- Midwest Heart and Vascular Specialists — Overland Park, Kansas
- Flourish Bowie — Bowie, Maryland
- Montefiore Medical Center - Bronx — Philadelphia, Pennsylvania
- Vital Heart and Vein — Humble, Texas
- Advara HeartCare Wesley — Auchenflower, Queensland
- University of The Sunshine Coast Clinical Trials, Sippy Downs — Sippy Downs, Queensland
- Advara HeartCare Leabrook — Leabrook, South Australia
- North York Diagnostic and Cardiac Centre — Vaughan, Ontario
- Peking University First Hospital — Beijing, Beijing Municipality
- The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan
- The Second Xiangya Hospital of Central South University — Changsha, Hunan
- The Third Xiangya Hospital of Central South University — Changsha, Hunan
- The Second Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu
- General Hospital of Ningxia Medical University — Yinchuan, Ningxia
- Shaanxi Provincial Peoples Hospital — Xi'an, Shaanxi
- Jinan Central Hospital — Jinan, Shandong
- Regionshospitalet Gødstrup — Herning,
- Regionshospitalet Viborg — Viborg,
- Centre Hospitalier Universitaire de Nice - Hopital Pasteur — Nice,
- Centre Hospitalier Universitaire de Bordeaux Hopital Haut-Leveque — Pessac,
- Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil — Toulouse,
- Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau — Tours,
- Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin — Berlin,
📞 Contact the Study Coordinator
Phone: (866) 572-6436
Email: medinfo@amgen.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cardiovascular Disease
- Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors — Québec,
- Hispanic Community Health Study / Study of Latinos — Chapel Hill, North Carolina
- EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction — Birmingham, Alabama
- Nitric Oxide Bioavailability and Early Life Stress (NO-Stress) — Augusta, Georgia
- Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease — Houston, Texas
- Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction — Los Angeles, California
Explore by condition: All Cardiovascular Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.