LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis (NCT07415044)
A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening.
Who can join: Review the eligibility criteria below.
Location: Valleywise Health Medical Center — Phoenix, Arizona
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (259 Sites)
Showing the first 25 of 259 sites.
- Valleywise Health Medical Center — Phoenix, Arizona
- One of a Kind Clinical Research Center — Scottsdale, Arizona
- Clinnova Research — Anaheim, California
- GMC Clinical Research — Folsom, California
- Om Research LLC — Temple City, California
- Om Research LLC — Victorville, California
- Peak Gastroenterology Associates — Colorado Springs, Colorado
- Advanced Research Institute - Denver — Denver, Colorado
- Rocky Mountain Gastroenterology Associates - Lakewood — Lakewood, Colorado
- Medical Research Center of Connecticut — Hamden, Connecticut
- K2 Medical Research - Daytona Beach — Daytona Beach, Florida
- Clinical Research of Osceola — Kissimmee, Florida
- Florida Research Institute — Lakewood Rch, Florida
- AdventHealth Orlando — Orlando, Florida
- Treasure Valley Medical Research — Boise, Idaho
- Grand Teton Research Group — Idaho Falls, Idaho
- Northwestern University — Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois
- Midwest Digestive Health & Nutrition — Des Plaines, Illinois
- Springfield Clinic - First — Springfield, Illinois
- Gastroenterology Health Partners — New Albany, Indiana
- Gastroenterology Health Partners — Louisville, Kentucky
- GI Alliance - Gastro Group and Endocenter - Mandeville — Mandeville, Louisiana
- Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center — Wyoming, Michigan
- Mayo Clinic in Rochester, Minnesota — Rochester, Minnesota
📞 Contact the Study Coordinator
Phone: (317) 615-4559
Email: LillyTrials@Lilly.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Ulcerative Colitis (UC)
- Evaluate the Safety, Tolerability, PK and PD of SAD of Intravenously Adminsterted ALTB-268 in Healthy Participants — Miami, Florida
- A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC) — Birmingham, Alabama
- A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis — Coronado, California
- A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC) — Mobile, Alabama
- Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy — Kelowna, British Columbia
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis — Miami, Florida
Explore by condition: All Ulcerative Colitis (UC) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.