A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) (NCT07440225)
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
🩺 Plain-English Summary (8th-Grade Level)
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Who can join: Review the eligibility criteria below.
Location: Research Network Arizona / Retina Macula Institute of Arizona — Scottsdale, Arizona
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (110 Sites)
Showing the first 25 of 110 sites.
- Research Network Arizona / Retina Macula Institute of Arizona — Scottsdale, Arizona
- Retina Center of Arkansas — Fayetteville, Arkansas
- Retina Partners of Northwest Arkansas, PLLC — Springdale, Arkansas
- Global Research Management, Inc. — Glendale, California
- Retinal Consultants Medical Group (Site 024) — Modesto, California
- Retina Consultants of Southern California (Site 043) — Redlands, California
- Retinal Consultants Medical Group (Site 020) — Sacramento, California
- Retinal Consultants Medical Group (Site 022) — Sacramento, California
- Florida Eye Clinic (Site 130) — Altamonte Springs, Florida
- Retina Group of Florida (Site 070) — Fort Lauderdale, Florida
- Vitreo Retinal Associates — Gainesville, Florida
- Florida Retina Institute — Jacksonville, Florida
- Retina Care Specialists — Palm Beach Gardens, Florida
- Fort Lauderdale Eye Institute (Site 042) — Plantation, Florida
- Retina Vitreous Associates of Florida (Site 049) — St. Petersburg, Florida
- Southern Vitreoretinal Associates — Tallahassee, Florida
- Retina Associates of Florida, LLC — Tampa, Florida
- Retina Vitreous Associates of Florida — Tampa, Florida
- Wildwood Clinical Research / Florida Retina Institute — Wildwood, Florida
- Illinois Retina Associates — Oak Park, Illinois
- Springfield Clinic — Springfield, Illinois
- Associated Vitreoretinal and Uveitis Consultants — Carmel, Indiana
- Midwest Eye Institute — Carmel, Indiana
- Cumberland Valley Retina Consultants (Site 007) — Hagerstown, Maryland
- Foundation for Vision Research (Site 073) — Grand Rapids, Michigan
📞 Contact the Study Coordinator
Phone: (888) 577-8839
Email: Trialsites@msd.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Macular Degeneration
- Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration — Mesa, Arizona
- Artificial Intelligence-assisted Diagnosis in Ophthalmology — Heredia, Centro
- Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss — Edina, Minnesota
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) — Gilbert, Arizona
- A Prospective Observational Study to Assess the Reliability and Validity of the MLSDT — Dallas, Texas
- Learning Study: Improving Vision in Adults With Macular Degeneration — Waterloo, Ontario
Explore by condition: All Macular Degeneration clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.