Progesterone Preeclampsia (NCT07448597)
Progesterone Supplementation for the Prevention of Preeclampsia
🩺 Plain-English Summary (8th-Grade Level)
This randomized controlled trial evaluates whether nightly vaginal micronized progesterone (400 mg) initiated before 12 weeks' gestation reduces the incidence of preeclampsia in low-risk pregnant individuals. Participants will be randomly assigned (1:1) to receive either vaginal progesterone through 16 weeks' gestation or routine prenatal care without progesterone. Maternal and neonatal outcomes-including development of preeclampsia, obstetric complications, gestational diabetes, preterm birth, and neonatal morbidity-will be collected via chart review. The study aims to determine whether early progesterone supplementation decreases the risk of preeclampsia.
Who can join: Review the eligibility criteria below.
Location: Medical University of South Carolina — Charleston, South Carolina
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Medical University of South Carolina — Charleston, South Carolina
📞 Contact the Study Coordinator
Phone: (716) 341-5115
Email: yacobucc@musc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Preeclampsia
- Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial — Pittsburgh, Pennsylvania
- Preeclampsia Postpartum Antihypertensive Treatment — Milwaukee, Wisconsin
- Preeclampsia Educational Program Study (PrEPS) — Long Beach, California
- Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients — Charlottesville, Virginia
- MR and Inflammation After Preeclampsia — Iowa City, Iowa
- Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention — Boston, Massachusetts
Explore by condition: All Preeclampsia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.