πŸ›οΈ Verified NIH Record β€’ Updated 2026-06-16

Methadone in the Management of Post-Operative Pain in Total Knee Replacement (NCT07485803)

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

🟒 Recruiting Phase4 πŸ’Š Investigational Drug / Biologic Sponsor: AdventHealth

🩺 Plain-English Summary (8th-Grade Level)

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Who can join: Review the eligibility criteria below.

Location: AdventHealth Porter β€” Denver, Colorado

Age range: 21 Years to 75 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (1 Sites)

  • AdventHealth Porter β€” Denver, Colorado

πŸ“ž Contact the Study Coordinator

Phone: (303) 260-2951

Email: makenna.hemmerle@adventhealth.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—