Mindfulness Engaged Neurostimulation for Depression (MEND II) (NCT07512284)
Mindfulness Engaged Neurostimulation for Depression
🩺 Plain-English Summary (8th-Grade Level)
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.
Who can join: Review the eligibility criteria below.
Location: UC San Diego Health Psychiatry — San Diego, California
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UC San Diego Health Psychiatry — San Diego, California
📞 Contact the Study Coordinator
Phone: (858) 232-2855
Email: braine@ucsd.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Depression
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- A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers — Houston, Texas
- EEG Biomarker Study for Participants in the Neurolief "MOOD" Trial — Providence, Rhode Island
- Using rTMS to Treat Depression — Miami, Florida
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Explore by condition: All Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.