A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer (NCT07659795)
A Phase 2, Open-label Study of VS-7375, an Oral KRAS G12D (ON/OFF) Inhibitor, With and Without an Anti-EGFR Antibody, and With an Anti-EGFR Antibody and Chemotherapy, in Patients With Metastatic KRAS G12D-Mutated Colorectal Adenocarcinoma (TARGET-D 203)
🩺 Plain-English Summary (8th-Grade Level)
This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab or panitumumab and cetuximab plus mFOLFOX in patients with metastatic KRAS G12D - mutated Colorectal Cancer
Who can join: Review the eligibility criteria below.
Location: START Los Angeles — Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- START Los Angeles — Los Angeles, California
- Valkyrie Clinical Trials (contact for more locations) — Los Angeles, California
- Moffitt Cancer Center — Tampa, Florida
- Indiana University, Simon Comprehensive Cancer Center — Indianapolis, Indiana
- START Midwest — Grand Rapids, Michigan
- START New Jersey — East Brunswick, New Jersey
- START Dallas Fort Worth — Fort Worth, Texas
- START Mountain Region — West Valley City, Utah
- UVA Comprehensive Cancer Center — Charlottesville, Virginia
- Icon Cancer Centre South Brisbane — South Brisbane, Queensland
- Icon Cancer Centre Adelaide — Kurralta Park, South Australia
📞 Contact the Study Coordinator
Phone: (781) 292-4204
Email: VS-7375-203TrialSupport@verastem.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.