Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD (NCT07674264)
A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease
🩺 Plain-English Summary (8th-Grade Level)
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.
Who can join: Review the eligibility criteria below.
Location: University of Florida — Gainesville, Florida
Age range: 40 Years to 75 Years
🧪 Interventions in This Study
- Acute intermittent hypercapnic hypoxia (AIHH) (OTHER)
- Acute intermittent hypercapnic normoxia (AIHN) (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- University of Florida — Gainesville, Florida
- Norman Fixel Institute for Neurological Diseases — Gainesville, Florida
📞 Contact the Study Coordinator
Phone: (352) 273-6095
Email: michela.mir@ufl.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.