78 Recruiting Studies at City Of Hope Comprehensive Cancer Center
Active clinical trials at this research center, sourced directly from the NIH registry.
π Duarte, California
All research centersRecruiting Studies at City Of Hope Comprehensive Cancer Center
Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia
Acute Myeloid Leukemia
View Study & Checklist βBrentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma
Adult T-Cell Leukemia/Lymphoma
View Study & Checklist βTesting the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines
Advanced Colorectal Carcinoma
View Study & Checklist βTesting the Addition of the Anti-cancer Viral Therapy Telomelysinβ’ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery
Advanced Esophageal Adenocarcinoma
View Study & Checklist βMethoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin
Advanced Malignant Solid Neoplasm
View Study & Checklist βAnti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma
Advanced Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
View Study & Checklist βEntinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer
Anatomic Stage III Breast Cancer AJCC v8
View Study & Checklist βDoxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma
Ann Arbor Stage I Hodgkin Lymphoma
View Study & Checklist βMetformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer
Atypical Ductal Breast Hyperplasia
View Study & Checklist βCellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia
B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma
View Study & Checklist βNutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery
Bladder Carcinoma
View Study & Checklist βCabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors
Bladder Small Cell Neuroendocrine Carcinoma
View Study & Checklist βATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer
Breast Cancer
View Study & Checklist βVeliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
Breast Carcinoma
View Study & Checklist βM6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Castration-Resistant Prostate Carcinoma
View Study & Checklist βCognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer
Castration-Resistant Prostatic Cancer
View Study & Checklist βCeralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors
Clear Cell Renal Cell Carcinoma
View Study & Checklist βTesting the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers
Clinical Stage III Esophageal Adenocarcinoma AJCC v8
View Study & Checklist βBerzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer
Clinical Stage III Gastric Cancer AJCC v8
View Study & Checklist βCancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
Colorectal Carcinoma
View Study & Checklist βTesting the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer
Differentiated Thyroid Gland Carcinoma
View Study & Checklist βHome Base Telemonitoring in Gastrointestinal, Genitourinary, or Gynecologic Cancer Patients Undergoing Abdominal Surgery
Digestive System Carcinoma
View Study & Checklist βTelehealth for the Self-Management of Dietary Quality of Life in Patients After Stomach Cancer Surgery
Gastric Carcinoma
View Study & Checklist βSorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate
Gastrointestinal Stromal Tumor
View Study & Checklist βTesting the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer
Head and Neck Carcinoma of Unknown Primary
View Study & Checklist βTesting the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck
Head and Neck Squamous Cell Carcinoma
View Study & Checklist βPhase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
Hodgkin Lymphoma, Adult
View Study & Checklist βTesting of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer
Leptomeningeal Neoplasm
View Study & Checklist βTesting Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma
Locally Advanced Extraskeletal Myxoid Chondrosarcoma
View Study & Checklist βTesting the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)
Locally Advanced Gastrointestinal Stromal Tumor
View Study & Checklist βTesting the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
Locally Advanced Malignant Solid Neoplasm
View Study & Checklist βA Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma
Lymphoma
View Study & Checklist βMolecular Profiling in Tissue Samples From Patients With Cancer Who Are Exceptional Responders to Treatment
Malignant Neoplasm
View Study & Checklist βFPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Metastatic Castration-resistant Prostate Cancer
View Study & Checklist βTesting the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors
Metastatic Lung Neuroendocrine Neoplasm
View Study & Checklist βOsimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor
Metastatic Lung Non-Small Cell Carcinoma
View Study & Checklist βTesting the Effectiveness of an Anti-cancer Drug, Triapine, When Used With Targeted Radiation-based Treatment (Lutetium Lu 177 Dotatate), Compared to Lutetium Lu 177 Dotatate Alone for Metastatic Neuroendocrine Tumors
Metastatic Neuroendocrine Tumor
View Study & Checklist βTesting the Addition of An Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Pancreatic Neuroendocrine Tumors
Neuroendocrine Neoplasm
View Study & Checklist βA Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
Non-Small Cell Lung Cancer
View Study & Checklist βGemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Ovarian Brenner Tumor
View Study & Checklist βIpilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia
Previously Treated Myelodysplastic Syndrome
View Study & Checklist βTesting the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study
Prostate Carcinoma
View Study & Checklist βTesting the Addition of an Anti-cancer Drug, M3814, to the Usual Treatment (Mitoxantrone, Etoposide, and Cytarabine) for Relapsed or Refractory Acute Myeloid Leukemia
Recurrent Acute Myeloid Leukemia
View Study & Checklist βVenetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis
Recurrent AL Amyloidosis
View Study & Checklist βTesting the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma
Recurrent Diffuse Large B-Cell Lymphoma
View Study & Checklist βA Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
Relapsed or Refractory Follicular Lymphoma
View Study & Checklist βNous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors
Solid Tumor, Adult
View Study & Checklist βMAGIC Ruxolitinib for aGVHD
Acute Graft-versus-host Disease
View Study & Checklist βA Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
Acute Myeloid Leukemia
View Study & Checklist βA Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia
View Study & Checklist βTesting the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial
Advanced Malignant Solid Neoplasm
View Study & Checklist βPersonalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)
Advanced Malignant Solid Neoplasm
View Study & Checklist βImmune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
AIDS-Related Diffuse Large B-cell Lymphoma
View Study & Checklist βTesting the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Astrocytoma, IDH-Mutant, Grade 2
View Study & Checklist βTesting Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
Astrocytoma, IDH-Mutant, Grade 3
View Study & Checklist βAcolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer
Breast Atypical Hyperplasia
View Study & Checklist βLYL273 for Patients With Relapsed or Refractory mCRC
Colorectal Cancer
View Study & Checklist βTesting the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
View Study & Checklist βThe da Vinci Single Port Robotic System for Use in Abdominal and Pelvic Surgical Procedures
Disease or Disorder
View Study & Checklist βA Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer
Endometrial Cancer
View Study & Checklist βTesting the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
Extensive Stage Lung Small Cell Carcinoma
View Study & Checklist βRemdesivir for the Treatment of Upper Respiratory Tract Infection Due to RSV in Immunocompromised Individuals
Hematopoietic and Lymphatic System Neoplasm
View Study & Checklist βTesting the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
Locally Advanced Pancreatic Adenocarcinoma
View Study & Checklist βStudying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
Metastatic Malignant Solid Neoplasm
View Study & Checklist βTesting the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
Metastatic Malignant Solid Neoplasm
View Study & Checklist βTesting the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors
Metastatic Pancreatic Neuroendocrine Tumor
View Study & Checklist βTesting the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells
Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation
View Study & Checklist βPembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy
Metastatic Urothelial Carcinoma
View Study & Checklist βA Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Neoplasms
View Study & Checklist βComparing the Effectiveness of the Immunotherapy Agents Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma, NORM Trial
Nodular Lymphocyte Predominant B-Cell Lymphoma
View Study & Checklist βA Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
Non-small Cell Lung Cancer
View Study & Checklist βA Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
Ovarian Cancer
View Study & Checklist βTesting the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia
Recurrent Chronic Lymphocytic Leukemia
View Study & Checklist βVenetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia
Recurrent Hairy Cell Leukemia
View Study & Checklist βTesting the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy
Recurrent Mantle Cell Lymphoma
View Study & Checklist βModified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Recurrent Mantle Cell Lymphoma
View Study & Checklist βTesting the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma
Recurrent Plasmablastic Lymphoma
View Study & Checklist βOpen-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Solid Tumor, Adult
View Study & Checklist β