100 Recruiting Studies at Massachusetts General Hospital
Active clinical trials at this research center, sourced directly from the NIH registry.
📍 Boston, Massachusetts
All research centersRecruiting Studies at Massachusetts General Hospital
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Circulating RNAs in Acute Congestive Heart Failure
Acute Congestive Heart Failure
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Acute Kidney Injury
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
DC/AML Fusion Cell Vaccine vs Observation in Patients Who Achieve a Chemotherapy-induced Remission
Acute Myelogenous Leukemia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS
Acute Myeloid Leukemia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
Acute Myeloid Leukemia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy
Adrenoleukodystrophy
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Study to Allow Patients Previously Participating in a Novartis Sponsored Trial to Continue Receiving Capmatinib Treatment as Single Agent or in Combination With Other Treatments or the Combination Treatment Alone
Advanced Solid Tumors Which Are cMET-dependent
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance
Aging
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS
Amyotrophic Lateral Sclerosis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic
Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration
Anesthesia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
Anosmia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Anxiety
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Addressing Anxiety in 2-3-Year-Olds: A Pilot Intervention Study
Anxiety Disorder of Childhood
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Prehabilitation for Aortic Aneurysm Surgery: Proof-of-concept Trial
Aortic Aneurysm
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Evaluation of PET/MR in Patients Selected for Ablation Therapy
Arrhythmias, Cardiac
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol
Lung-Resident Memory Th2 Cells in Asthma
Asthma, Allergic
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
Atherosclerosis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC
Attention Deficit Hyperactivity Disorder
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Melatonin and Sleep Spindles in Autism
Autism Spectrum Disorder
View Study & Checklist ➔ 🔵 Active, Not Recruiting Early Phase1 💊 Investigational Drug / Biologic
Fecal Microbiota Transplant for Autobrewery Syndrome
Auto-Brewery Syndrome
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
Barrett Esophagus
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule
Barrett's Esophagus
View Study & Checklist ➔ 🔵 Active, Not Recruiting Early Phase1 ⚙️ Medical Device Protocol
Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder
Bipolar
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Bipolar Disorder
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Brain Injury Traumatic Severe (Diagnosis)
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Pembrolizumab In Central Nervous System Metastases
Brain Metastases
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
Brain Tumor
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Prospective Assessment of Quality of Life (QOL) in Pediatric Patients Treated With Radiation Therapy for Brain Tumors and Non-central Nervous System (Non-CNS) Malignancies
Brain Tumors
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC
Breast Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
PORTAL: Patient-reported Outcomes After Routine Treatment of Atypical Lesions
Breast Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Onvansertib + Paclitaxel In TNBC
Breast Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
CDK 4/6 Inhibitor, Ribociclib, With Adjuvant Endocrine Therapy for ER-positive Breast Cancer
Breast Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients
Breast Cancer Stage II
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Innovating CBT-I for Cancer Survivors: An Optimization Trial
Cancer Survivorship
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.
Carcinoma, Non-Small-Cell Lung
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
A Randomized Clinical Trial to Measure Efficacy of Music on Cardiac Surgery Patients
Cardiac Surgery
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2
Cervical Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Virtual Health Insurance Navigation Pilot Program for Childhood Survivors (HINTII)
Childhood Cancer Survivors
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Personalized Antisense Oligonucleotide for A Single Participant With UBTF Gene Mutation
Childhood-Onset Neurodegeneration With Brain Atrophy (CONDBA)
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull
Chordoma of Spine
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain
Chronic Pain
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Vedolizumab for the Treatment of Collagenous Gastritis
Collagenous Gastritis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 💊 Investigational Drug / Biologic
ASPirin Intervention for the REDuction of Colorectal Cancer Risk
Colorectal Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Plasma ExtrAcellular RNAs and Biomarkers of Heart FaiLure During Decongestion: PEARL-HF Study
Congestive Heart Failure
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique
Coronary Arteriosclerosis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
Coronary Artery Disease
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
Coronary Artery Disease
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
COVID-19 Symptom Tracker
COVID-19
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis
Crohn's Disease
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic
Assessing Tenapanor as a Treatment of CF-related Constipation.
Cystic Fibrosis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Neuromodulation of Mind-Wandering in Depression
Depression
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma
Diffuse Large B Cell Lymphoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)
Dysexecutive Syndrome
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
The Role of Estrogen in the Neurobiology of Eating Disorders
Eating Disorders
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Preventing Disordered Eating and Body Dissatisfaction Among High-risk Pregnant Individuals
Eating Disorders
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus
Eosinophilic Esophagitis
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Genetic and Environmental Risk Factors Related to Esophageal Cancer
Esophageal Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Pilot Study for Evaluation of Cryobiopsy and Correlation With Standard Forceps Biopsy
Gastrointestinal Disease
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 💊 Investigational Drug / Biologic
Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
Genetics
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors
Germ Cell Tumor
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM
Glioblastoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Surgical Pembro +/- Olaparib w TMZ for rGBM
Glioblastoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Imaging Brain Fluids During Breathing
Healthy
View Study & Checklist ➔ 🔵 Active, Not Recruiting Early Phase1 💊 Investigational Drug / Biologic
Methemoglobin Concentration in High Dose Inhaled Nitric Oxide
Healthy Subjects
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
Hepatic Encephalopathy
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer
Hepatocellular Carcinoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA
HER-2 Positive Breast Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Bevacizumab In Hereditary Hemorrhagic Telangiectasia
Hereditary Hemorrhagic Telangiectasia
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Assess Safety and Efficacy of VAD044 in HHT Patients
Hereditary Hemorrhagic Telangiectasia (HHT)
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Open Pilot Trial of a Mind-Body Intervention for Patients With Chronic Hip Pain
Hip Pain
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Patient and Healthcare Professional Views on Genetic/Genomic Information and Testing
Hypogonadism, Hypogonadotropic
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
ACALA-R In Predominantly Demyelinating IgM Mediated Neuropathy
IgM MGUS
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe
Inflammatory Disease
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)
Iron-deficiency
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
Irritable Bowel Syndrome
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Delayed Tolerance Through Mixed Chimerism
Kidney Failure
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
KRAS G12C Mutant Solid Tumors
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
The Boston Pace Study
Left Bundle Branch Area Pacing
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Proton Radiation Therapy for Gliomas
Low Grade Glioma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Early Phase1 💊 Investigational Drug / Biologic
Niraparib In Recurrent IDH 1/2 Gliomas
Low-grade Glioma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Real-Time Image Guided Lymphatic Mapping and Nodal Targeting in Lung Cancer
Lung Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol
Mechanism of Action of Transcranial Magnetic Stimulation
Major Depressive Disorder
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation
Melanoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Pilot Study of a Brain Health Program in Senior Centers
Memory Loss (Excluding Dementia)
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol
A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas
Meningioma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)
Metastatic or Locally Advanced Unresectable Solid Tumors
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas
Metastatic Uveal Melanoma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer
Microsatellite Stable Colorectal Cancer
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
A Text- and Audio-based Intervention to Promote Physical Activity in Midlife
Middle Aged
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)
Mild Cognitive Impairment
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
Mood Disorders
View Study & Checklist ➔ 🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research
Mucolipidosis Type IV Natural History Study
Mucolipidosis Type IV
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic
Bortezomib, Lenalidomide and Dexamethasone Combination Therapy in Patients With Newly Diagnosed Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program
Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
KRDI in Transplant-Eligible MM
Multiple Myeloma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM
Multiple Myeloma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔ 🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic
Inqovi Maintenance Therapy in Myeloid Neoplasms
Myelodysplastic Syndromes
View Study & Checklist ➔