164 Recruiting Major Depressive Disorder Clinical Trials
Explore open interventional and observational research studies actively enrolling participants across the USA. Verify eligibility and contact site coordinators directly.
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Top Recruiting Major Depressive Disorder Studies
Fisher Wallace Neurostimulation & Depression Study
📍 ProofPilot (Remote Virtual Trial) — New York, New York
View Study & Checklist ➔Study to Assess the Safety and Effectiveness of NMRA-335140-501
📍 Neumora Investigator site — Huntsville, Alabama
View Study & Checklist ➔Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)
📍 UCLA Depression Research and Clinic Program — Los Angeles, California
View Study & Checklist ➔Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin
📍 Toronto Western Hospital — Toronto, Ontario
View Study & Checklist ➔Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
📍 VA Connecticut Healthcare System, West Haven Campus — West Haven, Connecticut
View Study & Checklist ➔Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
📍 Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine — West Haven, Connecticut
View Study & Checklist ➔Individualized Targeting and Neuromodulation of Late-Life Depression
📍 University of New Mexico HSC — Albuquerque, New Mexico
View Study & Checklist ➔Accelerated TMS for MDD
📍 Brighter Neurotherapeutics — New York, New York
View Study & Checklist ➔Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
📍 Johns Hopkins Center for Psychedelic and Consciousness Research — Baltimore, Maryland
View Study & Checklist ➔Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
📍 Mayo Clinic in Rochester — Rochester, Minnesota
View Study & Checklist ➔Imaging SV2A in Mood Disorders
📍 PET Center — New Haven, Connecticut
View Study & Checklist ➔Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
📍 Dauten Family Center for Bipolar Treatment Innovation — Boston, Massachusetts
View Study & Checklist ➔Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics
📍 Mayo Clinic Florida — Jacksonville, Florida
View Study & Checklist ➔DBS for TRD With the Medtronic Summit RC+S
📍 Icahn School of Medicine at Mount Sinai, Mount Sinai West — New York, New York
View Study & Checklist ➔A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder
📍 Kadima Neuropsychiatry Institute — La Jolla, California
View Study & Checklist ➔Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression Network
📍 The Royal Ottawa Mental Health Centre — Ottawa, Ontario
View Study & Checklist ➔"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
📍 Scottsdale Research Institute — Phoenix, Arizona
View Study & Checklist ➔A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)
📍 Preferred Research Partners, Inc — Little Rock, Arkansas
View Study & Checklist ➔Neurocognitive Effects of FMT in MDD Patients With and Without IBS
📍 University of Calgary, TRW building — Calgary, Alberta
View Study & Checklist ➔Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study
📍 Harding Hospital — Columbus, Ohio
View Study & Checklist ➔Getting Out of the House: Using Behavioral Activation to Increase Community Participation
📍 Temple University — Philadelphia, Pennsylvania
View Study & Checklist ➔Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression
📍 CHUM — Montreal, Quebec
View Study & Checklist ➔Clinical Validation of Samsung Smartwatch
📍 Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital — Boston, Massachusetts
View Study & Checklist ➔Open Label Optimization Study
📍 BrainHealth Solutions — Costa Mesa, California
View Study & Checklist ➔Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
📍 Medical University of South Carolina — Charleston, South Carolina
View Study & Checklist ➔Mechanism of Action of Transcranial Magnetic Stimulation
📍 Massachusetts General Hospital — Boston, Massachusetts
View Study & Checklist ➔Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression
📍 UT Center of Excellence on Mood Disorders — Houston, Texas
View Study & Checklist ➔Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Predictors of Cognitive Outcomes in Geriatric Depression
📍 UConn Health — Farmington, Connecticut
View Study & Checklist ➔EMA-Guided Maintenance TMS for Depression
📍 Butler Hospital — Providence, Rhode Island
View Study & Checklist ➔Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study
📍 University of California, San Francisco, Osher Center for Integrative Health — San Francisco, California
View Study & Checklist ➔Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression
📍 Stanford University — Stanford, California
View Study & Checklist ➔A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients
📍 Cedars-Sinai Health System — Los Angeles, California
View Study & Checklist ➔A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
📍 Local Institution - 0144 — Phoenix, Arizona
View Study & Checklist ➔Sustained Mood Improvement With Laughing Gas Exposure
📍 Sunnybrook Health Sciences Centre — Toronto, Ontario
View Study & Checklist ➔Sensory Synchronized Imaging and Neuromodulation
📍 VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California
View Study & Checklist ➔Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
📍 McLean Hospital — Belmont, Massachusetts
View Study & Checklist ➔Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
📍 St. Paul's Hospital — Vancouver, British Columbia
View Study & Checklist ➔RESISTance Exercise for Depression Trial
📍 Iowa State University — Ames, Iowa
View Study & Checklist ➔