🏛️ Verified NIH Record • Updated 2026-06-11
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation (NCT03347227)
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation (Coast-AF) Randomized Clinical Trial
🔵 Active, Not Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: Ottawa Heart Institute Research Corporation
🩺 Plain-English Summary (8th-Grade Level)
A multicentre, parallel group, two arm, single-blinded randomized clinical trial, assessing the efficacy of a patient-tailored catheter ablation (CA) strategy guided by atrial low voltage area mapping in addition to pulmonary vein isolation (PVI) when compared to PVI alone in patients with persistent atrial fibrillation (AF).
Who can join: Review the eligibility criteria below.
Location: Libin Cardiovascular Institute — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
- Catheter ablation (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- Libin Cardiovascular Institute — Calgary, Alberta
- Vancouver General Hospital — Vancouver, British Columbia
- QEII Health Sciences Centre, Nova Scotia Health Authority — Halifax, Nova Scotia
- Hamilton General Hospital — Hamilton, Ontario
- London Health Sciences Centre — London, Ontario
- Southlake Regional Health Centre — Newmarket, Ontario
- University of Ottawa Heart Institute — Ottawa, Ontario
- St. Michael's Hospital — Toronto, Ontario
- Rouge Valley Regional Heart Centre — Toronto, Ontario
- Centre Hospitalier de l'Universite de Montreal (CHUM) — Montreal, Quebec
- McGill University Health Centre — Montreal, Quebec
- Montreal Heart Institute — Montreal, Quebec
- Institute Universitaire de Cardiologie et Pneumologie du Quebec (IUCPQ) — Québec, Quebec
- CIUSSS de L'Estrie-CHUS-Hopital Fleurimont — Sherbrooke, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
- CHAMPION-AF Clinical Trial — Birmingham, Alabama
- Reversal of Atrial Substrate to Prevent Atrial — Calgary, Alberta
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
- REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry — Chandler, Arizona
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) — Cleveland, Ohio
- Liraglutide Effect in Atrial Fibrillation — Miami, Florida
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.