A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer (NCT03661320)
A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy Alone Versus Neoadjuvant Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Post- Surgery Therapy With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle- Invasive Bladder Cancer
π©Ί Plain-English Summary (8th-Grade Level)
The purpose of this study is to compare nivolumab plus neoadjuvant gemcitabine/cisplatin (GC) chemotherapy, followed by post-surgery continuation of immuno-oncology (IO) therapy, with neoadjuvant GC chemotherapy alone in adult participants with previously untreated muscle-invasive bladder cancer (MIBC).
Who can join: Review the eligibility criteria below.
Location: Local Institution - 0022 β Tucson, Arizona
Age range: 18 Years
π§ͺ Interventions in This Study
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (172 Sites)
Showing the first 25 of 172 sites.
- Local Institution - 0022 β Tucson, Arizona
- UC Davis Comprehensive Cancer Center β Sacramento, California
- Local Institution - 0021 β Littleton, Colorado
- Local Institution - 0036 β Pensacola, Florida
- Local Institution - 0004 β Tampa, Florida
- Local Institution - 0144 β Atlanta, Georgia
- Local Institution - 0005 β Chicago, Illinois
- Local Institution - 0006 β Peoria, Illinois
- Local Institution - 0181 β Columbia, Maryland
- Local Institution - 0009 β Boston, Massachusetts
- Local Institution - 0166 β Boston, Massachusetts
- Local Institution - 0209 β Boston, Massachusetts
- Local Institution - 0025 β Minneapolis, Minnesota
- Local Institution - 0129 β Minneapolis, Minnesota
- Local Institution - 0183 β Omaha, Nebraska
- Local Institution - 0001 β Omaha, Nebraska
- Local Institution - 0024 β Las Vegas, Nevada
- Local Institution - 0029 β Albany, New York
- Local Institution - 0069 β Lake Success, New York
- Local Institution - 0047 β New York, New York
- Local Institution - 0191 β Cleveland, Ohio
- Local Institution - 0028 β Tigard, Oregon
- Local Institution - 0189 β Charleston, South Carolina
- Local Institution - 0007 β Nashville, Tennessee
- Local Institution - 0030 β Austin, Texas
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Urinary Bladder Neoplasms
- A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder β Loma Linda, California
- A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU) β Birmingham, Alabama
- Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) β Washington D.C., District of Columbia
- A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-GuΓ©rin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy β Tucson, Arizona
- A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011) β Bakersfield, California
Explore by condition: All Urinary Bladder Neoplasms clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.