πŸ›οΈ Verified NIH Record β€’ Updated 2026-04-10

A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer (NCT03661320)

A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy Alone Versus Neoadjuvant Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Post- Surgery Therapy With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle- Invasive Bladder Cancer

πŸ”΅ Active, Not Recruiting Phase3 πŸ’Š Investigational Drug / Biologic Sponsor: Bristol-Myers Squibb

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to compare nivolumab plus neoadjuvant gemcitabine/cisplatin (GC) chemotherapy, followed by post-surgery continuation of immuno-oncology (IO) therapy, with neoadjuvant GC chemotherapy alone in adult participants with previously untreated muscle-invasive bladder cancer (MIBC).

Who can join: Review the eligibility criteria below.

Location: Local Institution - 0022 β€” Tucson, Arizona

Age range: 18 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (172 Sites)

Showing the first 25 of 172 sites.

  • Local Institution - 0022 β€” Tucson, Arizona
  • UC Davis Comprehensive Cancer Center β€” Sacramento, California
  • Local Institution - 0021 β€” Littleton, Colorado
  • Local Institution - 0036 β€” Pensacola, Florida
  • Local Institution - 0004 β€” Tampa, Florida
  • Local Institution - 0144 β€” Atlanta, Georgia
  • Local Institution - 0005 β€” Chicago, Illinois
  • Local Institution - 0006 β€” Peoria, Illinois
  • Local Institution - 0181 β€” Columbia, Maryland
  • Local Institution - 0009 β€” Boston, Massachusetts
  • Local Institution - 0166 β€” Boston, Massachusetts
  • Local Institution - 0209 β€” Boston, Massachusetts
  • Local Institution - 0025 β€” Minneapolis, Minnesota
  • Local Institution - 0129 β€” Minneapolis, Minnesota
  • Local Institution - 0183 β€” Omaha, Nebraska
  • Local Institution - 0001 β€” Omaha, Nebraska
  • Local Institution - 0024 β€” Las Vegas, Nevada
  • Local Institution - 0029 β€” Albany, New York
  • Local Institution - 0069 β€” Lake Success, New York
  • Local Institution - 0047 β€” New York, New York
  • Local Institution - 0191 β€” Cleveland, Ohio
  • Local Institution - 0028 β€” Tigard, Oregon
  • Local Institution - 0189 β€” Charleston, South Carolina
  • Local Institution - 0007 β€” Nashville, Tennessee
  • Local Institution - 0030 β€” Austin, Texas

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—