πŸ›οΈ Verified NIH Record β€’ Updated 2026-08-27

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder (NCT04658862)

A Phase 3, Multi-center, Randomized Study Evaluating Efficacy of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-Invasive Urothelial Carcinoma (MIBC) of the Bladder Who Are Not Receiving Radical Cystectomy

πŸ”΅ Active, Not Recruiting Phase3 πŸ’Š Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC

🩺 Plain-English Summary (8th-Grade Level)

The purpose of study is to compare bladder intact-event free survival (BI-EFS) in participants receiving TAR-200 in combination with intravenous (IV) cetrelimab versus concurrent chemoradiotherapy.

Who can join: Review the eligibility criteria below.

Location: Loma Linda Univ Faculty Medic β€” Loma Linda, California

Age range: 18 Years

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (290 Sites)

Showing the first 25 of 290 sites.

  • Loma Linda Univ Faculty Medic β€” Loma Linda, California
  • University of Southern California β€” Los Angeles, California
  • Providence Saint John s Health Center β€” Santa Monica, California
  • Stanford University Medical Center β€” Stanford, California
  • The Urology Center of Colorado β€” Denver, Colorado
  • Foothills Urology - Golden Off β€” Golden, Colorado
  • Boca Raton Regional Hospital β€” Boca Raton, Florida
  • Urological Research Network β€” Hialeah, Florida
  • Memorial Healthcare System β€” Pembroke Pines, Florida
  • Winship Cancer Institute of Emory University β€” Atlanta, Georgia
  • DuPage Medical Group β€” Lisle, Illinois
  • University Hospitals Seidman Cancer Center β€” Ann Arbor, Michigan
  • Michigan Institute of Urology β€” Troy, Michigan
  • Adult Pediatric Urology & Urogynecology, P.C β€” Omaha, Nebraska
  • Garden State Urology β€” Morristown, New Jersey
  • New Jersey Urology LLC β€” Voorhees Township, New Jersey
  • Cardiology Clinic at Montefiore Hutchinson Complex β€” The Bronx, New York
  • Duke University Medical Center β€” Durham, North Carolina
  • Vidant Urology - Greenville β€” Greenville, North Carolina
  • Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center β€” Winston-Salem, North Carolina
  • Wexner Medical Center at the Ohio State University β€” Columbus, Ohio
  • Stephenson Cancer Center β€” Oklahoma City, Oklahoma
  • MidLantic Urology β€” Bala-Cynwyd, Pennsylvania
  • Carolina Urologic Research Center β€” Myrtle Beach, South Carolina
  • University of Tennessee Medical Center β€” Knoxville, Tennessee

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—