Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression (NCT03952962)
🩺 Plain-English Summary (8th-Grade Level)
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. However, the effectiveness and safety is not well established. The investigators will use a novel approach using advanced imaging technique (magnetic resonance tractography) to evaluate the feasibility and safety of this surgical approach. An innovative method for the definition of DBS target will be applied that redefines the concept of targeting as one of targeting a symptomatic network rather than a structural brain region using subject-based brain anatomy to define the target location. The correlation between imaging findings at baseline with the mood score changes at different time points of the study will be investigated.
Who can join: Review the eligibility criteria below.
Location: UT Southwestern Medical Center — Dallas, Texas
Age range: 21 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UT Southwestern Medical Center — Dallas, Texas
📞 Contact the Study Coordinator
Phone: (310) 274-2095
Email: Nader.Pouratian@UTSouthwestern.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Treatment Resistant Depression
- Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S — Atlanta, Georgia
- Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression — Atlanta, Georgia
- An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) — Palo Alto, California
- Rapid Acting Transcranial Magnetic Stimulation — Stanford, California
- Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD) — Rochester, Minnesota
- Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression — Stanford, California
Explore by condition: All Treatment Resistant Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.