๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-13

Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG) (NCT04146051)

Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Cartesian Therapeutics

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis

Who can join: Review the eligibility criteria below.

Location: Profound Research โ€” Carlsbad, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (15 Sites)

  • Profound Research โ€” Carlsbad, California
  • University of California Irvine โ€” Irvine, California
  • University of Colorado Anschutz Medical Campus โ€” Aurora, Colorado
  • SFM Clinical Research, LLC โ€” Boca Raton, Florida
  • Neurology Associates, P.A. โ€” Orlando, Florida
  • University of South Florida โ€” Tampa, Florida
  • University of Augusta โ€” Augusta, Georgia
  • University of Kansas Medical Center Research Institute โ€” Kansas City, Kansas
  • Dent Neurologic Institute โ€” Amherst, New York
  • University of North Carolina โ€” Chapel Hill, North Carolina
  • Oregon Health & Science University โ€” Portland, Oregon
  • University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • Allegheny Health Network โ€” Pittsburgh, Pennsylvania
  • Virginia Commonwealth University โ€” Richmond, Virginia
  • University of Alberta โ€” Edmonton, Alberta

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—