๐๏ธ Verified NIH Record โข Updated 2026-08-13
Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG) (NCT04146051)
Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)
๐ต Active, Not Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Cartesian Therapeutics
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Who can join: Review the eligibility criteria below.
Location: Profound Research โ Carlsbad, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (15 Sites)
- Profound Research โ Carlsbad, California
- University of California Irvine โ Irvine, California
- University of Colorado Anschutz Medical Campus โ Aurora, Colorado
- SFM Clinical Research, LLC โ Boca Raton, Florida
- Neurology Associates, P.A. โ Orlando, Florida
- University of South Florida โ Tampa, Florida
- University of Augusta โ Augusta, Georgia
- University of Kansas Medical Center Research Institute โ Kansas City, Kansas
- Dent Neurologic Institute โ Amherst, New York
- University of North Carolina โ Chapel Hill, North Carolina
- Oregon Health & Science University โ Portland, Oregon
- University of Pennsylvania โ Philadelphia, Pennsylvania
- Allegheny Health Network โ Pittsburgh, Pennsylvania
- Virginia Commonwealth University โ Richmond, Virginia
- University of Alberta โ Edmonton, Alberta
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Myasthenia Gravis, Generalized
- A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC) โ Phoenix, Arizona
- Study of Aritinercept in Patients With Generalized Myasthenia Gravis โ Pasadena, California
- A Phase 3 Study to Evaluate Claseprubart in Adults With Generalized Myasthenia Gravis (EMERGE) โ Boca Raton, Florida
- A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis โ Mission Hills, California
Explore by condition: All Myasthenia Gravis, Generalized clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.