🏛️ Verified NIH Record • Updated 2026-07-23
A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC) (NCT06282159)
A Phase 2, Randomized, Blinded, Placebo-Controlled, Study to Evaluate Safety, Tolerability, Pharmacometrics, and Efficacy of DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC)
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Dianthus Therapeutics
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this Phase 2 study is to evaluate the safety, tolerability, pharmacometrics, and efficacy of DNTH103 in participants with generalized myasthenia gravis (gMG).
Who can join: Review the eligibility criteria below.
Location: Clinical Study Site — Phoenix, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (56 Sites)
Showing the first 25 of 56 sites.
- Clinical Study Site — Phoenix, Arizona
- Clinical Study Site — Irvine, California
- Clinical Study Site — Stamford, Connecticut
- Clinical Study Site — Boca Raton, Florida
- Clinical Study Site — Bradenton, Florida
- Clinical Study Site — Maitland, Florida
- Clincal Study Site — Tampa, Florida
- Clinical Study Site — O'Fallon, Illinois
- Clinical Study Site — Kansas City, Kansas
- Clinical Study Site — Lexington, Kentucky
- Clinical Study Site — Boston, Massachusetts
- Clinical Study Site — East Lansing, Michigan
- Clinical Study Site — Columbia, Missouri
- Clinical Study Site — Cincinnati, Ohio
- Clinical Study Site — Columbus, Ohio
- Clinical Study Site — Dallas, Texas
- Clinical Study Site — Dallas, Texas
- Clinical Study Site #2 — Houston, Texas
- Clinical Study Site — Houston, Texas
- Clinical Study Site — Lubbock, Texas
- Clinical Study Site — Richmond, Virginia
- Clinical Study Site — San Miguel de Tucumán, Tucumán Province
- Clinical Study Site — Buenos Aires,
- Clinical Study Site — Buenos Aires,
- Clinical Study Site — Buenos Aires,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Myasthenia Gravis, Generalized
- Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG) — Carlsbad, California
- Study of Aritinercept in Patients With Generalized Myasthenia Gravis — Pasadena, California
- A Phase 3 Study to Evaluate Claseprubart in Adults With Generalized Myasthenia Gravis (EMERGE) — Boca Raton, Florida
- A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis — Mission Hills, California
Explore by condition: All Myasthenia Gravis, Generalized clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.