STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation (NCT04428944)
Strategies for Catheter Ablation of Persistent Atrial Fibrillation: a Randomized, Comparative Study
🩺 Plain-English Summary (8th-Grade Level)
The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: 1. PV antral isolation alone (PVAI) 2. PV antral isolation plus ablation of drivers (PVAI+drivers) 3. PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation technology using more efficient open irrigated tip cooling and contact force sensing.
Who can join: Review the eligibility criteria below.
Location: Brigham & Women'S Hosptial Inc. — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
- Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI) (PROCEDURE)
- Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers) (PROCEDURE)
- Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box) (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- Brigham & Women'S Hosptial Inc. — Boston, Massachusetts
- Canberra Heart Rhythm Foundation — Garran, Australian Capital Territory
- Royal Adelaide Hospital and Cardiovascular Centre — Adelaide,
- Alfred Health — Melbourne,
- Royal Melbourne Hospital — Parkville,
- Medical University of Graz — Graz,
- Ordensklinikum Linz GmbH — Linz,
- OLV Hospital Aalst — Aalst,
- Antwerp University Hospital (UZA) — Edegem,
- AZ Sint-Jan — Ruddershove,
- University of Calgary Foothills — Calgary, Alberta
- Vancouver General Hospital — Vancouver, British Colombia
- St. Paul's Hospital, Vancouver, BC — Vancouver, British Colombia
- Royal Jubilee Hospital — Victoria, British Colombia
- Hamilton General Hospital — Hamilton, Ontario
- Southlake Regional Health Center — Newmarket, Ontario
- Laurent Macle — Montreal, QC - Québec
- MUHC, McGill University Health Centre — Montreal, Quebec
- University of Ottawa Heart Institute — Ottawa, Quebec
- Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) — Québec, Quebec
- Hôpital Fleurimont, CHUS — Sherbrooke, Quebec
- Hospital St-Joseph — Marseille,
- Institut Mutualiste Montsouris — Paris,
- Clinique du Tonkin — Villeurbanne,
- Ospedale Generale Regionale F. Miulli — Acquaviva delle Fonti,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
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- Reversal of Atrial Substrate to Prevent Atrial — Calgary, Alberta
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
- REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry — Chandler, Arizona
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) — Cleveland, Ohio
- Liraglutide Effect in Atrial Fibrillation — Miami, Florida
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.