🏛️ Verified NIH Record • Updated 2026-07-03
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy (NCT04629248)
A Phase III Randomized, Open-Label Active Comparator-Controlled Multicenter Study to Evaluate Efficacy and Safety of Obinutuzumab in Patients With Primary Membranous Nephropathy
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Hoffmann-La Roche
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).
Who can join: Review the eligibility criteria below.
Location: Kaiser Permanente - San Francisco Medical Center — San Francisco, California
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (50 Sites)
Showing the first 25 of 50 sites.
- Kaiser Permanente - San Francisco Medical Center — San Francisco, California
- University of Colorado in Denver-Anschutz Medical Campus — Aurora, Colorado
- Accel Research Sites; Mid-Florida Kidney and Hypertension Care — Altamonte Springs, Florida
- University of Iowa — Iowa City, Iowa
- Henry Ford Hospital — Detroit, Michigan
- Mayo Clinic — Rochester, Minnesota
- Columbia University Medical Center — New York, New York
- Nephrotex Research Group — Dallas, Texas
- Organizacion Medica de Investigacion — Buenos Aires,
- CINME — Buenos Aires,
- Hospital Britanico Buenos Aires — Buenos Aires,
- Ser Servicos Especializados Em Reumatologia — Salvador, Estado de Bahia
- Hospital de Base de Sao Jose do Rio Preto — São José do Rio Preto, São Paulo
- Hospital do Rim e Hipertensão - Fundação Oswaldo Ramos — São Paulo, São Paulo
- Hospital das Clinicas - FMUSP — São Paulo, São Paulo
- Zhejiang Provincial People?s Hospital — Hangzhou, Zhejiang
- Peking University First Hospital — Beijing,
- Sichuan Provincial People's Hospital — Chengdu,
- The 1st Affiliated hospital of Fujian Medical University — Fuzhou,
- Nanfang Hospital, Southern Medical University — Guangzhou,
- Ruijin Hospital, Shanghai Jiaotong University School of Medicine — Shanghai,
- Huashan Hospital, Fudan University — Shanghai,
- Tongji Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan,
- The First Affiliated Hospital of Xian Jiao Tong University — Xi'an,
- General Hospital of Ningxia Medical University — Yinchuan,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Primary Membranous Nephropathy
- A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy — Granada Hills, California
- Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN) — Montgomery, Alabama
- Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN) — Loma Linda, California
- A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN) — Huntsville, Alabama
- A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy — Denver, Colorado
Explore by condition: All Primary Membranous Nephropathy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.