A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy (NCT05707377)
A Phase 2/3, Multicenter, Randomized, Active-Controlled, Open-label Study to Evaluate the Efficacy and Safety of Zanubrutinib in Patients With Primary Membranous Nephropathy
๐ฉบ Plain-English Summary (8th-Grade Level)
The primary objectives of this study are: In Part 1 to evaluate the efficacy of zanubrutinib as measured by proteinuria reduction, and in Part 2 to evaluate the efficacy of zanubrutinib compared with tacrolimus as measured by complete remission rate, in participants with primary membranous nephropathy (PMN) who are on optimal supportive care.
Who can join: Review the eligibility criteria below.
Location: Amicis Research Center โ Granada Hills, California
Age range: 18 Years to 75 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (47 Sites)
Showing the first 25 of 47 sites.
- Amicis Research Center โ Granada Hills, California
- Stanford University โ Palo Alto, California
- Intermed Consultants โ Minneapolis, Minnesota
- Kidney Specialist of Southern Nevada (Ksosn) โ Las Vegas, Nevada
- University of Cincinnati College of Medicine โ Cincinnati, Ohio
- Carolina Nephrology โ Spartanburg, South Carolina
- Instituto Pro Renal Brasil โ Curitiba,
- Ott Healthcare, Inc (Corporate Medical Centre) โ Scarborough Village, Ontario
- Beijing An Zhen Hospital, Capital Medical University โ Beijing, Beijing Municipality
- Peking University First Hospital โ Beijing, Beijing Municipality
- Fujian Medical University Union Hospital โ Fuzhou, Fujian
- The First Affiliated Hospital of Fujian Medical University โ Fuzhou, Fujian
- The First Affiliated Hospital of Xiamen University โ Xiamen, Fujian
- Guangdong Provincial Peoples Hospital โ Guangzhou, Guangdong
- The First Affiliated Hospital, Sun Yat Sen University โ Guangzhou, Guangdong
- Peking University Shenzhen Hospital โ Shenzhen, Guangdong
- The First Affiliated Hospital of Guangxi Medical University โ Nanning, Guangxi
- Guizhou Provincial Peoples Hospital โ Guiyang, Guizhou
- The First Hospital of Hebei Medical University โ Shijiazhuang, Hebei
- The Second Affiliated Hospital of Harbin Medical University โ Harbin, Heilongjiang
- Nanyang Central Hospital โ Nanyang, Henan
- The First Affiliated Hospital of Zhengzhou University โ Zhengzhou, Henan
- Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology โ Wuhan, Hubei
- Renmin Hospital of Wuhan University โ Wuhan, Hubei
- The First Affiliated Hospital of Baotou Medical College โ Baotou, Inner Mongolia
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Primary Membranous Nephropathy
- A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy โ San Francisco, California
- Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN) โ Montgomery, Alabama
- Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN) โ Loma Linda, California
- A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN) โ Huntsville, Alabama
- A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy โ Denver, Colorado
Explore by condition: All Primary Membranous Nephropathy clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.