๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-31

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN) (NCT07204275)

A Phase 2b/3 Adaptive, Randomized, Active-controlled Study Evaluating the Efficacy, Safety, and Tolerability of Povetacicept Versus Calcineurin Inhibitor in the Treatment of Primary Membranous Nephropathy

๐ŸŸข Recruiting Phase2 / Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Vertex Pharmaceuticals Incorporated

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).

Who can join: Review the eligibility criteria below.

Location: Renal Associates โ€” Montgomery, Alabama

Age range: 18 Years to 75 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (111 Sites)

Showing the first 25 of 111 sites.

  • Renal Associates โ€” Montgomery, Alabama
  • Southwest Kidney Institute, PLC (SKI) - Surprise โ€” Surprise, Arizona
  • Academic Medical Research Institute (AMRI) โ€” Los Angeles, California
  • Valiance Clinical Research - Internal Medicine โ€” Tarzana, California
  • Western Nephrology & Metabolic Bone Disease PC โ€” Arvada, Colorado
  • Bioresearch Partner โ€” Miami, Florida
  • CTR Oakwater, LLC โ€” Orlando, Florida
  • Clinical Site Partners, LLC - Orlando โ€” Winter Park, Florida
  • DaVita Clinical Research Columbus โ€” Columbus, Georgia
  • Georgia Nephrology โ€” Lawrenceville, Georgia
  • CARE Institute-Boise Kidney โ€” Boise, Idaho
  • NANI Research โ€” Hinsdale, Illinois
  • DaVita Clinical Research Edina โ€” Edina, Minnesota
  • St. Clair Nephrology Research โ€” Roseville, Missouri
  • Kidney Specialists of Southern Nevada โ€” Las Vegas, Nevada
  • NYU Medical Center โ€” New York, New York
  • Carolina Nephrology Greenville โ€” Greenville, South Carolina
  • Carolina Nephrology, PA โ€” Spartanburg, South Carolina
  • El Paso Kidney Specialists โ€” El Paso, Texas
  • Provecta Research Network โ€” Houston, Texas
  • DaVita Clinical Research Houston โ€” Houston, Texas
  • Davita Clinical Research San Antonio โ€” San Antonio, Texas
  • Utah Kidney Research โ€” Salt Lake City, Utah
  • Milwaukee Neprologists, SC โ€” Wauwatosa, Wisconsin
  • Monash Medical Centre โ€” Clayton,

๐Ÿ“ž Contact the Study Coordinator

Phone: 001-617-341-6777

Email: medicalinfo@vrtx.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—