Who is eligible for clinical trial NCT04644068?

Participants must meet protocol criteria for Ovarian Cancer. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04644068 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-18

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies (NCT04644068)

A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: Research Site — Boston, Massachusetts

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (68 Sites)

Showing the first 25 of 68 sites.

Research Site — Boston, Massachusetts
Research Site — Boston, Massachusetts
Research Site — New York, New York
Research Site — Oklahoma City, Oklahoma
Research Site — Houston, Texas
Research Site — Heidelberg,
Research Site — Melbourne,
Research Site — Vancouver, British Columbia
Research Site — Toronto, Ontario
Research Site — Montreal, Quebec
Research Site — Montreal, Quebec
Research Site — Beijing,
Research Site — Changchun,
Research Site — Changsha,
Research Site — Chengdu,
Research Site — Chongqing,
Research Site — Guangzhou,
Research Site — Harbin,
Research Site — Jining,
Research Site — Shandong,
Research Site — Shanghai,
Research Site — Shanghai,
Research Site — Taiyuan,
Research Site — Wuhan,
Research Site — Xi'an,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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Trial on Radical Upfront Surgery in Advanced Ovarian Cancer — New York, New York
Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) — Duarte, California
Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302) — Little Rock, Arkansas
NeoVax With Nivolumab in Patients With Ovarian Cancer — Boston, Massachusetts

Explore by condition: All Ovarian Cancer clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗