Matching Perfusion and Metabolic Activity in HFpEF (NCT04913805)
🩺 Plain-English Summary (8th-Grade Level)
This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).
Who can join: Review the eligibility criteria below.
Location: University of Pennsylvania — Philadelphia, Pennsylvania
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Pennsylvania — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (267) 253-6141
Email: fernand@pennmedicine.upenn.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure With Preserved Ejection Fraction
- Physical Activity, Cardiac and Skeletal Muscle Energetics in Healthy Subjects and HFpEF Patients — Baltimore, Maryland
- Cardiac Rehab Effects in HFpEF — Salt Lake City, Utah
- Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction — Naples, Florida
- IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency — Durham, North Carolina
- Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction — Kelowna, British Columbia
Explore by condition: All Heart Failure With Preserved Ejection Fraction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.