🏛️ Verified NIH Record • Updated 2026-07-31
Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction (NCT05839730)
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Medtronic Cardiac Rhythm and Heart Failure
🩺 Plain-English Summary (8th-Grade Level)
FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements in exercise capacity and health status of subjects.
Who can join: Review the eligibility criteria below.
Location: NCH Heart Institute — Naples, Florida
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (8 Sites)
- NCH Heart Institute — Naples, Florida
- Prairie Education and Research Cooperative-St. Elizabeth's — O'Fallon, Illinois
- Prairie Education and Research Cooperative-St. John's — Springfield, Illinois
- University of Kansas Medical Center — Kansas City, Kansas
- Duke University — Durham, North Carolina
- Oklahoma Heart Hospital — Oklahoma City, Oklahoma
- Houston Methodist Research Institute — Houston, Texas
- The University of Vermont Medical Center — Burlington, Vermont
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure With Preserved Ejection Fraction
- Physical Activity, Cardiac and Skeletal Muscle Energetics in Healthy Subjects and HFpEF Patients — Baltimore, Maryland
- Cardiac Rehab Effects in HFpEF — Salt Lake City, Utah
- IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency — Durham, North Carolina
- Matching Perfusion and Metabolic Activity in HFpEF — Philadelphia, Pennsylvania
- Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction — Kelowna, British Columbia
Explore by condition: All Heart Failure With Preserved Ejection Fraction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.