Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY (NCT04916210)
🩺 Plain-English Summary (8th-Grade Level)
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.
Who can join: Review the eligibility criteria below.
Location: Barrow Neurological Institute — Phoenix, Arizona
Age range: 18 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (31 Sites)
Showing the first 25 of 31 sites.
- Barrow Neurological Institute — Phoenix, Arizona
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Cedars Sinai Medical Center — Los Angeles, California
- University of California Los Angeles — Los Angeles, California
- University of California San Diego — San Diego, California
- University of Colorado — Denver, Colorado
- Mayo Clinic — Jacksonville, Florida
- University of Miami Health System — Miami, Florida
- The University of Chicago Medical Center — Chicago, Illinois
- Indiana University — Indianapolis, Indiana
- University of Iowa — Iowa City, Iowa
- University of Maryland Medical Center — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Boston Medical Center — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- University of Minnesota Health — Minneapolis, Minnesota
- Mayo Clinic — Rochester, Minnesota
- University of Mississippi Medical Center — Jackson, Mississippi
- Icahn School of Medicine at Mount Sinai — New York, New York
- Montefiore Medical Center — The Bronx, New York
- Duke University Medical Center — Durham, North Carolina
- Wake Forest Baptist Health — Winston-Salem, North Carolina
- University of Cincinnati — Cincinnati, Ohio
- The Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania
- Methodist University Hospital — Memphis, Tennessee
📞 Contact the Study Coordinator
Phone: (904) 953-6515
Email: meschia.james@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.