๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-01-05

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC (NCT04919811)

A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Nuvation Bio Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.

Who can join: Review the eligibility criteria below.

Location: Beverly Hills Cancer Center โ€” Beverly Hills, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (77 Sites)

Showing the first 25 of 77 sites.

  • Beverly Hills Cancer Center โ€” Beverly Hills, California
  • The Oncology Institute of Hope and Innovation โ€” Glendale, California
  • Moores Cancer Center at UC San Diego โ€” La Jolla, California
  • Keck Medicine of University of Southern California โ€” Los Angeles, California
  • UCI Medical Center โ€” Orange, California
  • Ventura County Hematology-Oncology Specialists โ€” Oxnard, California
  • SCRI - Florida Cancer Specialists South โ€” Fort Meyers, Florida
  • Memorial Cancer Institute at Memorial Hospital East โ€” Hollywood, Florida
  • Cancer Specialists of North Florida โ€” Jacksonville, Florida
  • Memorial Cancer Institute at Memorial Hospital West โ€” Pembroke Pines, Florida
  • SCRI - Hematology Oncology Clinic โ€” Baton Rouge, Louisiana
  • Mayo Clinic โ€” Rochester, Minnesota
  • Center for Cancer Research โ€” Brick, New Jersey
  • Cleveland Clinic Foundation โ€” Cleveland, Ohio
  • SCRI - Tennessee Oncology โ€” Nashville, Tennessee
  • Texas Oncology, P.A. โ€” Dallas, Texas
  • Renovatio Clinical โ€” El Paso, Texas
  • MD Anderson Cancer Center โ€” Houston, Texas
  • Renovatio Clinical โ€” The Woodlands, Texas
  • Northwest Medical Specialties, PLLC โ€” Tacoma, Washington
  • Princess Margaret Cancer Centre โ€” Toronto, Ontario
  • McGill University Health Centre Research Institute โ€” Montreal, Quebec
  • Beijing Cancer Hospital โ€” Beijing, Beijing Municipality
  • The First Affiliated Hospital of Zhengzhou University โ€” Zhengzhou, Henan
  • Shanghai Pulmonary Hospital โ€” Shanghai, Shanghai Municipality

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—