๐๏ธ Verified NIH Record โข Updated 2026-01-05
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC (NCT04919811)
A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors
๐ต Active, Not Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Nuvation Bio Inc.
๐ฉบ Plain-English Summary (8th-Grade Level)
The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.
Who can join: Review the eligibility criteria below.
Location: Beverly Hills Cancer Center โ Beverly Hills, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (77 Sites)
Showing the first 25 of 77 sites.
- Beverly Hills Cancer Center โ Beverly Hills, California
- The Oncology Institute of Hope and Innovation โ Glendale, California
- Moores Cancer Center at UC San Diego โ La Jolla, California
- Keck Medicine of University of Southern California โ Los Angeles, California
- UCI Medical Center โ Orange, California
- Ventura County Hematology-Oncology Specialists โ Oxnard, California
- SCRI - Florida Cancer Specialists South โ Fort Meyers, Florida
- Memorial Cancer Institute at Memorial Hospital East โ Hollywood, Florida
- Cancer Specialists of North Florida โ Jacksonville, Florida
- Memorial Cancer Institute at Memorial Hospital West โ Pembroke Pines, Florida
- SCRI - Hematology Oncology Clinic โ Baton Rouge, Louisiana
- Mayo Clinic โ Rochester, Minnesota
- Center for Cancer Research โ Brick, New Jersey
- Cleveland Clinic Foundation โ Cleveland, Ohio
- SCRI - Tennessee Oncology โ Nashville, Tennessee
- Texas Oncology, P.A. โ Dallas, Texas
- Renovatio Clinical โ El Paso, Texas
- MD Anderson Cancer Center โ Houston, Texas
- Renovatio Clinical โ The Woodlands, Texas
- Northwest Medical Specialties, PLLC โ Tacoma, Washington
- Princess Margaret Cancer Centre โ Toronto, Ontario
- McGill University Health Centre Research Institute โ Montreal, Quebec
- Beijing Cancer Hospital โ Beijing, Beijing Municipality
- The First Affiliated Hospital of Zhengzhou University โ Zhengzhou, Henan
- Shanghai Pulmonary Hospital โ Shanghai, Shanghai Municipality
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.