A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors (NCT04931342)
A Phase II, Open-Label, Multicenter, Platform Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase.
Who can join: Review the eligibility criteria below.
Location: UCSF Helen Diller Family CCC — San Francisco, California
Age range: 18 Years
🧪 Interventions in This Study
- Ipatasertib (DRUG)
- Cobimetinib (DRUG)
- Trastuzumab Emtansine (DRUG)
- Atezolizumab (DRUG)
- Bevacizumab (DRUG)
- Paclitaxel (DRUG)
- Giredestrant (DRUG)
- Abemaciclib (DRUG)
- Inavolisib (DRUG)
- Palbociclib (DRUG)
- Letrozole (DRUG)
- Olaparib (DRUG)
- Luteinizing Hormone-Releasing Hormone (LHRH) Agonists (DRUG)
- Cyclophosphamide (DRUG)
- Inavolisib (DRUG)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (41 Sites)
Showing the first 25 of 41 sites.
- UCSF Helen Diller Family CCC — San Francisco, California
- Washington University School of Medicine — St Louis, Missouri
- Levine Cancer Institute — Charlotte, North Carolina
- Ohio State University — Columbus, Ohio
- University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma
- Texas Oncology - Gulf Coast — The Woodlands, Texas
- Virginia Oncology Associates — Norfolk, Virginia
- University of Washington - Seattle Cancer Care Alliance — Seattle, Washington
- Cabrini Hospital — Malvern, Victoria
- Princess Margaret Cancer Center — Toronto, Ontario
- McGill University Health Centre - Glen Site — Montreal, Quebec
- Gynekologicko-porodnicka klinika — Prague,
- CHU Besançon - Hôpital Jean Minjoz — Besançon,
- Centre Francois Baclesse — Caen,
- Centre Leon Berard — Lyon,
- Groupe Hospitalier Diaconesses — Paris,
- Centre Eugène Marquis — Rennes,
- ICO - Site René Gauducheau — Saint-Herblain,
- Institut Claudius Regaud — Toulouse,
- Gustave Roussy — Villejuif,
- Kliniken Essen-Mitte Evang. Huyssens-Stiftung, Klinik für Gynäkologie und gynäkologische Onkologie — Essen,
- Universitätsklinikum Mannheim — Mannheim,
- A.O. U. Consorziale Policlinico di Bari — Bari, Apulia
- Istituto Tumori Napoli — Naples, Campania
- Policlinico Universitario Agostino Gemelli — Rome, Lazio
📞 Contact the Study Coordinator
Phone: (877) 827-3222
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Safety and Efficacy of Anti-CD47, ALX148 in Combination With Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer — Pittsburgh, Pennsylvania
- Trial on Radical Upfront Surgery in Advanced Ovarian Cancer — New York, New York
- Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) — Duarte, California
- Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302) — Little Rock, Arkansas
- NeoVax With Nivolumab in Patients With Ovarian Cancer — Boston, Massachusetts
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.