🏛️ Verified NIH Record • Updated 2026-01-19
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3) (NCT05026866)
A Study of Donanemab Versus Placebo in Participants at Risk for Cognitive and Functional Decline of Alzheimer's Disease
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Eli Lilly and Company
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks. Approximately 800 additional participants will be enrolled in the 12-month Addendum 7 to assess safety of a different titration regimen.
Who can join: Review the eligibility criteria below.
Location: Parkway Medical Center — Birmingham, Alabama
Age range: 55 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (216 Sites)
Showing the first 25 of 216 sites.
- Parkway Medical Center — Birmingham, Alabama
- Alabama Psychiatry - Birmingham - Brookwood Medical Center Drive — Homewood, Alabama
- Rehabilitation & Neurological Services — Huntsville, Alabama
- Care Access - 801 South Power Road, Mesa — Mesa, Arizona
- Banner Alzheimer's Institute — Phoenix, Arizona
- Banner Alzheimer's Institute Tucson — Tucson, Arizona
- Center for Neurosciences — Tucson, Arizona
- Care Access - Berkeley — Berkeley, California
- Care Access - Beverly Hills — Beverly Hills, California
- Velocity Clinical Research, Chula Vista — Chula Vista, California
- Valley Clinical Trials, Inc. — Covina, California
- Neurology Center of North Orange County — Fullerton, California
- Care Access - Gilroy — Gilroy, California
- Marvel Clinical Research — Huntington Beach, California
- Care Access Research - Huntington Beach — Huntington Beach, California
- Irvine Clinical Research — Irvine, California
- Option Care - Irvine — Irvine, California
- Kaizen Brain Center — La Jolla, California
- Velocity Clinical Research, San Diego — La Mesa, California
- Pacific Research Network — Lemon Grove, California
- Healthy Brain Clinic — Long Beach, California
- Neurovations — Napa, California
- Care Access - Newport Beach — Newport Beach, California
- Valley Clinical Trials, Inc. — Northridge, California
- Inland Psychiatric Medical Group — Redlands, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Alzheimer Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.