Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS) (NCT05354141)
Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles for Hospitalized Patients With Moderate-to-Severe ARDS: A Phase III Clinical Trial
🩺 Plain-English Summary (8th-Grade Level)
To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitalized patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
Who can join: Review the eligibility criteria below.
Location: Direct Biologics Investigational Site — Phoenix, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- Direct Biologics Investigational Site — Phoenix, Arizona
- Direct Biologics Investigational Site — Little Rock, Arkansas
- Direct Biologics Investigational Site — Davis, California
- Direct Biologics Investigational Site — Irvine, California
- Direct Biologics Investigational Site — Sacramento, California
- Direct Biologics Investigational Site — Washington D.C., District of Columbia
- Direct Biologics Investigational Site — Jacksonville, Florida
- Direct Biologics Investigational Site — Boise, Idaho
- Direct Biologics Investigational Site — Iowa City, Iowa
- Direct Biologics Investigational Site — Silver Spring, Maryland
- Direct Biologics Investigational Site — Boston, Massachusetts
- Direct Biologics Investigational Site — Burlington, Massachusetts
- Direct Biologics Investigational Site — Springfield, Massachusetts
- Direct Biologics Investigational Site — Detroit, Michigan
- Direct Biologics Investigational Site — Rochester, Minnesota
- Direct Biologics Investigational Site — Jackson, Mississippi
- Direct Biologics Investigational Site — Flushing, New York
- Direct Biologics Investigational Site — Queens, New York
- Direct Biologics Investigational Site — The Bronx, New York
- Direct Biologics Investigational Site — Durham, North Carolina
- Direct Biologics Investigational Site — Winston-Salem, North Carolina
- Direct Biologics Investigational Site — Cincinnati, Ohio
- Direct Biologics Investigational Site — Cleveland, Ohio
- Direct Biologics Investigational Site — Portland, Oregon
- Direct Biologics Investigational Site — Charleston, South Carolina
📞 Contact the Study Coordinator
Phone: (800) 791-1021
Email: clinicalaffairs@directbiologics.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Acute Respiratory Distress Syndrome
- Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway — Calgary, Alberta
- Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS) — Boston, Massachusetts
- ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND) — Birmingham, Alabama
- Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome — Tucson, Arizona
- Macrophage Programing in Acute Lung Injury: MiniBAL — Denver, Colorado
- Vascular ARDS Recruitment After Inhaled Nitric Oxide — Boston, Massachusetts
Explore by condition: All Acute Respiratory Distress Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.