Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial) (NCT05382208)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of antibiotic-resistant bacterial infections.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 30 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- University of California Los Angeles — Los Angeles, California
- University of California San Diego — San Diego, California
- Miami University — Miami, Florida
- Emory University — Atlanta, Georgia
- Tulane University — New Orleans, Louisiana
- Johns Hopkins University School of Medicine — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Washington University School of Medicine — St Louis, Missouri
- SUNY Downstate Medical School — Brooklyn, New York
- Weill Cornell Medicine — New York, New York
- University of North Carolina — Chapel Hill, North Carolina
- Duke University School of Medicine — Durham, North Carolina
- University of Cincinnati College of Medicine — Cincinnati, Ohio
- Case Western University — Cleveland, Ohio
- Ohio State University — Columbus, Ohio
- Temple University — Philadelphia, Pennsylvania
- University of Pittsburgh — Pittsburgh, Pennsylvania
- University of Texas, McGovern Medical School — Houston, Texas
- University of Washington — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Emphysema
- Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema — Iowa City, Iowa
- Zephyr Valve Registry (ZEVR) — Birmingham, Alabama
- Emphysema Research Registry and Biosample Repository — Pittsburgh, Pennsylvania
- Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum — Hamilton, Ontario
- STRIVE Post-Market Registry Study — Phoenix, Arizona
Explore by condition: All Emphysema clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.