๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-03-16

RESPONDER-HF Trial (NCT05425459)

Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy in Mildly Reduced or Preserved Ejection Fraction (EF) Heart Failure (Protocol #2201)

๐Ÿ”ต Active, Not Recruiting Observational / Diagnostic โš™๏ธ Medical Device Protocol Sponsor: Corvia Medical

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Multicenter, Prospective, Randomized, Sham Controlled, Double Blinded Clinical Trial, with; 1:1 randomization

Who can join: Review the eligibility criteria below.

Location: Arizona Cardiovascular Research Center โ€” Phoenix, Arizona

Age range: 40 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (61 Sites)

Showing the first 25 of 61 sites.

  • Arizona Cardiovascular Research Center โ€” Phoenix, Arizona
  • Scripps Clinic โ€” La Jolla, California
  • MemorialCare Long Beach Medical Center โ€” Long Beach, California
  • Christiana Care Health Services โ€” Newark, Delaware
  • Memorial Regional Hospital โ€” Hollywood, Florida
  • NCH Naples โ€” Naples, Florida
  • Cleveland Clinic Florida โ€” Weston, Florida
  • Northside Hospital Gwinnett Campus โ€” Lawrenceville, Georgia
  • Wellstar Kennestone โ€” Marietta, Georgia
  • Northwestern University โ€” Chicago, Illinois
  • University of Chicago Medical Center โ€” Chicago, Illinois
  • Endeavor Health-Northshore โ€” Glenview, Illinois
  • LSU Health Shreveport โ€” Shreveport, Louisiana
  • Lahey Hospital & Medical Center โ€” Burlington, Massachusetts
  • UMass Memorial Hospital University Campus โ€” Worcester, Massachusetts
  • University of Michigan Health Systems โ€” Ann Arbor, Michigan
  • Mayo Clinic Rochester โ€” Rochester, Minnesota
  • Hackensack University Medical Center โ€” Hackensack, New Jersey
  • Weill Cornell โ€” New York, New York
  • Christ Hospital โ€” Cincinnati, Ohio
  • University of Cincinatti Medical Center โ€” Cincinnati, Ohio
  • Cleveland Clinic OH โ€” Cleveland, Ohio
  • Ohio State University Wexner medical Center โ€” Columbus, Ohio
  • St. Francis Hospital (Heart Hospital) โ€” Tulsa, Oklahoma
  • OHSU Hospital โ€” Portland, Oregon

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Heart Failure clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—