[18F]PI-2620 Phase 3 Histopathological Study (NCT05641688)
An Open-label, Non-randomized, Multi-center Pivotal Phase 3 Study to Evaluate the Efficacy and Safety of PET Imaging With [18F]PI-2620 for the Detection of Tau Deposition When Compared to Post-mortem Histopathology (ADvance)
🩺 Plain-English Summary (8th-Grade Level)
This study is an open-label, multi-center, non-randomized pivotal Phase 3 study to assess the efficacy and safety of PET imaging with \[18F\]PI-2620 for detection of tau deposition in subjects with Alzheimer's disease (AD) and controls during lifetime when compared to histopathology obtained after death and completion of brain autopsy.
Who can join: Review the eligibility criteria below.
Location: Barrow Neurological Institute — Phoenix, Arizona
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (25 Sites)
- Barrow Neurological Institute — Phoenix, Arizona
- Banner Sun Health Research Institute — Sun City, Arizona
- UC Los Angeles — Los Angeles, California
- Esperanza Clinical — Murrieta, California
- Sutter Health — San Francisco, California
- Galiz Research — Hialeah, Florida
- UF College of Medicine - Jacksonville — Jacksonville, Florida
- K2 Medical Research — Lady Lake, Florida
- K2 Medical Research — Maitland, Florida
- ClinCloud Research — Melbourne, Florida
- Miami Jewish Health Systems — Miami, Florida
- The Roskamp Institute — Sarasota, Florida
- Charter Research — Winter Park, Florida
- Alzheimer's Disease Center — Braintree, Massachusetts
- Headlands Research — Plymouth, Massachusetts
- Be Well Clinical Studies — Lincoln, Nebraska
- Darthmouth-Hitchcock Medical Center — Lebanon, New Hampshire
- Velocity Clinical Research — East Syracuse, New York
- Ichor Research — Syracuse, New York
- American Carolina Clinical Research LLC — Charlotte, North Carolina
- Insight Clinical Trials LLC — Beachwood, Ohio
- Valley Medical Research — Centerville, Ohio
- Baylor Research Institute — Dallas, Texas
- Sante Clinical Research — Kerrville, Texas
- Be Well Clinical Studies — Round Rock, Texas
📞 Contact the Study Coordinator
Phone: +49 (0)30 461 1246 03
Email: clinicaltrials@life-mi.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.