🏛️ Verified NIH Record • Updated 2026-08-27
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation (NCT05757869)
A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants With Atrial Fibrillation
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.
Who can join: Review the eligibility criteria below.
Location: Advanced Cardiovascular, LLC — Alexander City, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1052 Sites)
Showing the first 25 of 1052 sites.
- Advanced Cardiovascular, LLC — Alexander City, Alabama
- Ascension St. Vincent's Health System — Birmingham, Alabama
- SEC Clinical Research — Dothan, Alabama
- HH Heart Center and Heart Center — Huntsville, Alabama
- CB Flock Research Corporation — Mobile, Alabama
- Mercy Gilbert Medical Center — Gilbert, Arizona
- Valleywise Health Medical Center — Phoenix, Arizona
- Arizona Arrhythmia Research Center — Phoenix, Arizona
- Arizona Heart Hospital — Phoenix, Arizona
- HonorHealth Neurology 1 — Scottsdale, Arizona
- HonorHealth Neurology — Scottsdale, Arizona
- Arkansas Heart Hospital — Little Rock, Arkansas
- Bakersfield Memorial Hospital — Bakersfield, California
- Vitality Clinical Research — Beverly Hills, California
- Chula Vista Cardiac Clinic — Chula Vista, California
- Sharp Chula Vista Medical Center — Chula Vista, California
- Mission Cardiovascular Research Institute — Fremont, California
- Paradise Clinical Research Group LLC — Glendora, California
- Miller Children's at Long Beach Medical Center — Long Beach, California
- Los Angeles Cardiology Associates — Los Angeles, California
- University of Southern California — Los Angeles, California
- Merced Vein and Vascular Center — Merced, California
- Radin Cardiovascular Medical Group — Newport Beach, California
- California Medical Research Associates, Inc. — Northridge, California
- Valley Clinical Trials, Inc. — Northridge, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
- CHAMPION-AF Clinical Trial — Birmingham, Alabama
- Reversal of Atrial Substrate to Prevent Atrial — Calgary, Alberta
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
- REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry — Chandler, Arizona
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) — Cleveland, Ohio
- Liraglutide Effect in Atrial Fibrillation — Miami, Florida
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.