Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis (NCT05835895)
A Phase 1b, Randomized, Double-Blinded, Placebo-Controlled Dose Ranging Study to Evaluate Safety, Tolerability and Pharmacodynamics of a Single Intra-articular Injection of GNSC-001 Gene Therapy in Subjects With Osteoarthritis of the Knee
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful osteoarthritis (OA) of the knee.
Who can join: Review the eligibility criteria below.
Location: Alliance for Medical Research Mobile — Mobile, Alabama
Age range: 40 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- Alliance for Medical Research Mobile — Mobile, Alabama
- Biosolutions Clinical Research Center — La Mesa, California
- UC San Diego — San Diego, California
- Well Pharma Medical Research — Miami, Florida
- South Florida Research — Miami Springs, Florida
- Premier Medical Associates — The Villages, Florida
- Alliance for Multispecialty Research Kansas City — Kansas City, Missouri
- West Clinical Research — Morehead City, North Carolina
- Altoona Center for Clinical Research — Duncansville, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Osteoarthritis, Knee
- The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness — Hamilton, Ontario
- Genicular Radiofrequency Ablation Following Total Knee Arthroplasty — Calgary, Alberta
- Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis — Sacramento, California
- Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain — Tempe, Arizona
- Prospective Randomized Study of Cementless vs Cemented UKA — New Albany, Ohio
- Clinical Outcomes of Joint Arthroplasty — St. Helena, California
Explore by condition: All Osteoarthritis, Knee clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.