Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine (NCT05962229)
🩺 Plain-English Summary (8th-Grade Level)
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Who can join: Review the eligibility criteria below.
Location: Zuckerberg San Francisco General Hospital (ZSFG) — San Francisco, California
Age range: 21 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Zuckerberg San Francisco General Hospital (ZSFG) — San Francisco, California
📞 Contact the Study Coordinator
Phone: (628) 206-4204
Email: lisa.lawrence@ucsf.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- NeuroControl of Nicotine Dependence — Columbia, Missouri
- Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use — Los Angeles, California
- Orexin s Role in the Neurobiology of Substance Use Disorder — Baltimore, Maryland
Explore by condition: All Nicotine Dependence clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.