The Fourth Left Atrial Appendage Occlusion Study (NCT05963698)
The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)
🩺 Plain-English Summary (8th-Grade Level)
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
Who can join: Review the eligibility criteria below.
Location: Affinity Hospital dba Grandview Medical Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (140 Sites)
Showing the first 25 of 140 sites.
- Affinity Hospital dba Grandview Medical Center — Birmingham, Alabama
- Arrhythmia Research Group — Jonesboro, Arkansas
- Memorial Health Services — Fountain Valley, California
- Loma Linda University Health — Loma Linda, California
- Southern California Permanente Medical Group — Pasadena, California
- Sutter Valley Hospitals dba Sutter Institute for Medical Research — Sacramento, California
- JFK Medical Center Limited Partnership d/b/a HCA Florida JFK Hospital — Atlantis, Florida
- St. Vincent's Health System — Jacksonville, Florida
- Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical Center — Largo, Florida
- HCA Florida Ocala Hospital — Ocala, Florida
- The University of South Florida — Tampa, Florida
- Emory University — Atlanta, Georgia
- St Luke's Regional Medical Center, Ltd — Boise, Idaho
- Kootenai Health Inc. — Coeur d'Alene, Idaho
- Northwestern University — Evanston, Illinois
- Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island — Rock Island, Illinois
- Community Health Network Inc. — Indianapolis, Indiana
- MercyOne Iowa Heart Center — West Des Moines, Iowa
- University of Kansas Medical Center Research Institute, Inc. — Kansas City, Kansas
- Babtist Health Lexington — Lexington, Kentucky
- Ochsner Clinic Foundation — New Orleans, Louisiana
- University of Maryland Baltimore — Baltimore, Maryland
- Lahey Clinic Inc. — Burlington, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Henry Ford Health System — Detroit, Michigan
📞 Contact the Study Coordinator
Phone: (905) 521-2100
Email: LAAOS-4@phri.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
- CHAMPION-AF Clinical Trial — Birmingham, Alabama
- Reversal of Atrial Substrate to Prevent Atrial — Calgary, Alberta
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
- REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry — Chandler, Arizona
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) — Cleveland, Ohio
- Liraglutide Effect in Atrial Fibrillation — Miami, Florida
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.